Nicox announces that its Exclusive Licensee Submits response to CRL for latanoprostene bunod ophthalmic solution, 0.024%

August 17, 2017, 10:33 pm

≫ Next: MITHRA ANNOUNCES FIRST SUBJECT COMPLETES ESTELLE® PHASE III STUDY

≪ Previous: SeaBird Exploration: Second quarter 2017 report

*Press Release*
Nicox announces that its Exclusive Licensee Submits response to CRL for latanoprostene bunod ophthalmic solution, 0.024%

August 18, 2017
Sophia Antipolis, France

*Nicox S.A.* (Euronext Paris: FR0013018124, COX), the international ophthalmic company, today announced that its exclusive licensee has informed Nicox that it has submitted a response to the Complete Response Letter (CRL) received from the U.S. Food and Drug Administration (FDA) on August 7, 2017 concerning the New Drug Application (NDA) for latanoprostene bunod ophthalmic solution, 0.024% for the reduction of intraocular pressure in patients with glaucoma or ocular hypertension.

*About latanoprostene bunod*

Latanoprostene bunod is a single agent therapy eye drop with a dual mode of action. Upon instillation in the eye, latanoprostene bunod works by metabolizing into two moieties, latanoprost acid and butanediol mononitrate, each targeting a specific pathway; the first, latanoprost acid, a prostaglandin F2-alpha analog, primarily works within the uveoscleral pathway to increase aqueous humor outflow and the second, butanediol mononitrate, releases nitric oxide to increase outflow through the trabecular meshwork and Schlemm's canal.
*About Nicox*
Nicox S.A. is an international ophthalmic company developing innovative solutions to help maintain vision and improve ocular health. By leveraging its proprietary expertise in nitric oxide donation and other technologies, the Company is developing an extensive portfolio of novel drug candidates that target multiple ophthalmic conditions, including glaucoma. Nicox currently has one product, through its exclusive licensee, at the review stage with the U.S. Food and Drug Administration (FDA), latanoprostene bunod ophthalmic solution, 0.024%, and one product with an approved NDA, ZERVIATE (cetirizine ophthalmic solution) 0.24%. In addition our promising drug-candidate pipeline includes a next-generation of stand-alone nitric-oxide donors and exploratory novel NO-donating compounds, as well as repurposing of existing molecules with the potential to offer novel approaches to treat a range of ophthalmic conditions. Nicox is headquartered in Sophia Antipolis, France, is listed on Euronext Paris (Compartment B: Mid Caps; Ticker symbol: COX) and is part of the CAC Healthcare, CAC Pharma & Bio and Next 150 indexes.

For more information on Nicox, its products or pipeline, please visit: www.nicox.com .
*Analyst coverage*
Bryan, Garnier & Co Hugo Solvet Paris, France
Invest Securities Martial Descoutures Paris, France
Gilbert Dupont Damien Choplain Paris, France

The views expressed by analysts in their coverage of Nicox are those of the author and do not reflect the views of Nicox. Additionally, the information contained in their reports may not be correct or current. Nicox disavows any obligation to correct or to update the information contained in analyst reports.

*Upcoming financial and business conferences*

September 25-27 Cantor Fitzgerald's 3rd Annual Healthcare Conference New York; US
November 23-24 Actionnaria Paris, France

*Contacts*
*Nicox*
Gavin Spencer,
Executive Vice President Corporate Development
T +33 (0)4 97 24 53 00
communications@nicox.com
*Investor Relations*
Europe
Nicox
Corporate Communications Department
T +33 (0)4 97 24 53 00
communications@nicox.com

* Media Relations
* United Kingdom
Jonathan Birt
T +44 7860 361 746
jonathan.birt@ymail.com
United States
Argot Partners
Melissa Forst
T +1 (212) 600-1902
melissa@argotpartners.com France
NewCap
Nicolas Merigeau
T +33 (0)1 44 71 94 98
nicox@newcap.eu
* * United States
Argot Partners
Eliza Schleifstein
T +1 (917) 763-8106
eliza@argotpartners.com
*Disclaimer*
The information contained in this document may be modified without prior notice. This information includes forward-looking statements. Such forward-looking statements are not guarantees of future performance. These statements are based on current expectations or beliefs of the management of Nicox S.A. and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Nicox S.A. and its affiliates, directors, officers, employees, advisers or agents, do not undertake, nor do they have any obligation, to provide updates or to revise any forward-looking statements.

Risks factors which are likely to have a material effect on Nicox's business are presented in the 4th chapter of the ' Document de référence, rapport financier annuel et rapport de gestion 2016 ' filed with the French Autorité des Marchés Financiers (AMF) on March 29, 2017, and in the updated and additional risk factors as of August 14, 2017, which are available on Nicox's website (www.nicox.com).
*Nicox S.A.*
Drakkar 2
Bât D, 2405 route des Dolines
CS 10313, Sophia Antipolis
06560 Valbonne, France
T +33 (0)4 97 24 53 00
F +33 (0)4 97 24 53 99

Press release
--------------------This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: NICOX via GlobeNewswire

HUG#2127940 Reported by GlobeNewswire 1 hour ago.

↧

MITHRA ANNOUNCES FIRST SUBJECT COMPLETES ESTELLE® PHASE III STUDY

August 17, 2017, 10:33 pm

≫ Next: Police stop second attack in town of Cambrils after 13 killed in Barcelona

≪ Previous: Nicox announces that its Exclusive Licensee Submits response to CRL for latanoprostene bunod ophthalmic solution, 0.024%

*MIThRA ANNOUNCES first subject completes *

*ESTELLE® PhAse III study*

· *Estelle* ® *Phase III studies remain on track to report top line results in Q3 2018 and Q1 2019 in Europe/Russia and the US/Canada respectively*

*Liège, Belgium, 18 August 2017* - Mithra (Euronext Brussels: MITRA), a company specialized in Women's Health, today announces that the first European study subject has successfully completed 13 cycles of Estelle® and the end of study physician visit in the E4 Freedom Phase III study program. Estelle® is Mithra's combined oral contraceptive (COC) candidate, composed of 15 mg Estetrol (E4) and 3 mg Drospirenone (DRSP), and is currently being tested in two Phase III trials in Europe/Russia and in the US/Canada.

Mithra announced in February 2017 that recruitment was completed in Europe and Russia and top line data remain on track to be reported during Q3 2018. For the Phase III study in the US and Canada, which was initiated in September 2016, all sites are now actively recruiting subjects, with completion of recruitment expected in the near future and top line data expected during Q1 2019.

*François Fornieri, CEO of Mithra, commented:* "Today's news is another positive step in the development of Estelle® which remains on track to report top line results in Q3 2018 for Europe/Russia and in Q1 2019 for US/Canada. The first woman successfully completing 13 cycles with Estelle® and others nearing completion provides an encouraging indication of the user acceptance and well-being of subjects using our novel COC product candidate. We look forward to reporting the Phase III results, which we believe will show that Estelle® offers women a convenient and potentially safer contraceptive alternative to currently available treatments."

*European Phase III study design (Estelle®)*

The European Phase III Estelle® study design is an open-label single arm study that enrolled 1577 subjects aged 18-50 years of whom 1350 treated subjects are aged 18-35 years. The objectives of the study are to evaluate the contraceptive's efficacy, cycle control, and the general safety and acceptability of the 15 mg Estetrol (E4) and 3 mg DRSP combination oral contraceptive pill in healthy women aged 18-50 years old.

The study is taking place in 69 centres across Europe and Russia, and involves subject participation for a period of minimum 12 months (13 cycles, 1 cycle = 28 days). The primary outcome is contraceptive efficacy in the 18-35 year old group based on the Pearl Index, which measures the number of pregnancies per 100 women per 12 months of exposure.

Secondary outcomes include cycle control and bleeding profile, safety and tolerability, general wellbeing of the subjects (measured by two questionnaires) and any adverse impact on the endometrium. This last parameter will be evaluated based on approximately 170 subjects out of the 1577 enrolled.

*For more information, please contact:*

* Investor Relations *

*Sofie Van Gijsel, IRO*
+32 485 19 14 15
investorrelations@mithra.com
s vangijsel@mithra.com

*
Consilium Strategic Communication
* Jonathan Birt, Sue Stuart, Philippa Gardner, Hendrik Thys *
* mithra@consilium-comms.com *
* +44 2 037 095 700

* Press *

*Julie Dessart*
Chief Communication Officer
+32 4 349 28 22 / +32 475 86 41 75

press@mithra.com

*About Mithra*

Mithra (Euronext: MITRA) is dedicated to providing innovation and choice in Women's Health, with a particular focus on fertility, contraception and menopause. Mithra's goal is to develop new and improved products that meet women's needs for better safety and convenience. Its two lead development candidates - a fifth generation oral contraceptive Estelle® and next-generation hormone therapy Donesta® - are built on Mithra's unique natural estrogen platform, E4 (Estetrol). Mithra also develops, manufactures and markets complex therapeutics and offers partners a complete spectrum of research, development and specialist manufacturing at its CDMO. Mithra was founded in 1999 as a spin-off from the University of Liège by Mr. François Fornieri and Prof. Dr. Jean-Michel Foidart. Mithra is headquartered in Liège, Belgium. Further information can be found at: www.mithra.com

*Important information*

The contents of this announcement include statements that are, or may be deemed to be, "forward-looking statements". These forward-looking statements can be identified by the use of forward-looking terminology, including the words "believes", "estimates,""anticipates", "expects", "intends", "may", "will", "plans", "continue", "ongoing", "potential", "predict", "project", "target", "seek" or "should", and include statements the Company makes concerning the intended results of its strategy. By their nature, forward-looking statements involve risks and uncertainties and readers are cautioned that any such forward-looking statements are not guarantees of future performance. The Company's actual results may differ materially from those predicted by the forward-looking statements. The Company undertakes no obligation to publicly update or revise forward-looking statements, except as may be required by law.

To subscribe to Mithra's mailing list, visit investors.mithra.com
--------------------This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: Mithra Pharmaceuticals via GlobeNewswire

HUG#2127912 Reported by GlobeNewswire 1 hour ago.

↧

Police stop second attack in town of Cambrils after 13 killed in Barcelona

August 17, 2017, 11:00 pm

≫ Next: What We Are Dealing With: Trump Or Democracy – OpEd

≪ Previous: MITHRA ANNOUNCES FIRST SUBJECT COMPLETES ESTELLE® PHASE III STUDY

Police stop second attack in town of Cambrils after 13 killed in Barcelona

Catalan police said today that the situation in Cambrils, south of Barcelona, was under control after they killed five people in an operation following yesterday's Barcelona van attack.

A van ploughed into crowds in Barcelona's Las Ramblas yesterday afternoon, killing 13 and injuring a hundred others. The driver of the van fled and is still at large.

*Read more*: Barcelona terrorist attack: Van mows into crowded tourist spot killing 13

Spain's Prime Minister Mariano Rajoy called it a "jihadist attack" and said on Twitter: "The terrorists will never defeat a united people who love freedom in the face of barbarism.

"All of Spain is with the victims and families."

https://twitter.com/mossos/status/898364664278642688

In Cambrils, seven people including a police officer were wounded when a car was driven into a group of people earlier on today in a similar attack to yesterday's in Barcelona, according to Catalan emergency services.

Spanish media reported that when the men got out, some appeared to be wearing explosive belts, and they were fired upon by police, before a series of controlled explosions was carried out.

Police said the situation in seaside resort Cambrils is now under control.

They have also posted an emergency number for families affected yesterday.

https://twitter.com/mossos/status/898375714310959105

Vehicles have been used to plough into crowds in a series of attacks in Europe since July last year when a truck was rammed into crowds celebrating Bastille Day in Nice, killing 86 people. A Christmas market in Berlin was targeted in December, while this year there was the Westminster Bridge, London Bridge and Finsbury Park attacks in the capital.

*Read more*: The London Bridge attackers tried to hire a lorry, police say Reported by City A.M. 56 minutes ago.

↧

What We Are Dealing With: Trump Or Democracy – OpEd

August 17, 2017, 11:15 pm

≫ Next: Barcelona van attack kills 13 in agonizing repeat for Europe

≪ Previous: Police stop second attack in town of Cambrils after 13 killed in Barcelona

Although it is still not sure if Donald Trump will go down in history as champion of bombastic, but empty threats, or as somebody who did what he threatened with, thus starting a dangerous local war with potentially global consequences, one thing is absolutely sure: Donald Trump, the eccentric billionaire with a turbulent business career, a showman, proved with his entry into the White House, but as well as with the campaign waged by the so called liberals (in the best way of almost forgotten McChartism) to evict him from there, that the model of western democracy, especially its American version, is irreparable corrupted. If we look at the facts as they are, there can be no doubt about this.

Trump was elected as president of America, a country that was for decades, with good reason, viewed as the light-bearer of democracy. He was elected in accordance with the rules of the American democratic system, rules that are – basically – applied from the very beginning of the existence of the United States. Here we stumble upon the first “but”. Only to enter the race for the nomination for the presidential candidate, one must have money, very much money. In democracy, meaning the rule of the people, the people are robbed of the possibility to elect the best and forced to elect among the rich the one, who seems to be most capable. Or, and this is the second “but” (which was obviously the case in the last elections), people are left to choose and to decide who is the lesser evil. This is why, choosing between Trump, who at that time presented a fresh and for America even radically changed foreign policy program and the former First lady and Secretary of State, an undisputed political hawk with no other foreign policy program that the continuation of toppling regimes in foreign countries and installing those who suited the US best and – not to forget – the continuation of the reborn Cold war, people opted for Trump, as lesser evil. Of course, when we use the term “people” we have in mind those who decided to use their voting right, which is usually about 50% of those registered as potential voters. And here is the third “but”. The President is elected by the minority of the Americans and imposed upon the majority.

This is how American democracy functions, at least in the last couple of decades. But, being strongly influenced by everything coming from America, similar trends are more and more present in Europe too. In other words, system we call democracy and we praise as “something that is not perfect, but there is nothing better than it” (as the legendary British prime minister form the times of WW 2, Winston Churchill once said), is giving all chances and opening all doors not to those who are capable, but to those who are rich. This very system often forces the voters to choose only between the greater and lesser evil. And in many countries (France was, at least until today, an exception) the voters are to such a degree fed up with politics, with politicians and with the scandals accompanying them, that they in significant numbers simply abstain from their right to vote, leaving it to the minority to impose its choice to the majority. And this should be the rule of the people?

But let us deal with facts, as they are. Trump was elected in the same way as all his predecessors. He was not unique (meaning the first) even because of the fact that his opponent won more popular votes, but he won the elections due to the electoral votes. To put it as simply as possible: he won in a democratic way and his victory was legitimate. And here begins the second chapter of the saga about the corrupted democracy. Despite the fact that he was democratically elected, despite the fact the legality of his election could not have been disputed, followers of the candidate who lost (and in whom the disoriented left leaning European liberals all of a sudden see a leftist – what she never was!) started with help of the mainstream media, either friendly to them or controlled by them (free media, is it?) an unprecedented campaign against Trump. His “main sin”, needless to say is, according to them, that he won due to the Russian meddling in the election process – which is a gigantic compliment to the Russian propaganda and secret services, but at the same time an even greater offence to the American voters. Parallel to this Trump’s mental health, his ability to perform the duties of the President and – more recently – his threat to start a nuclear war are being discussed.

The champion of the anti-Trump campaign, the global TV network, CNN, already discusses his state of mind (his accountability, to put it bluntly), the degree of his connection with Moscow (a second detant is obviously something very frightening for Trump’s political adversaries) and finally the mechanisms of impeachment. The special prosecutor investigating the alleged ties between Trump and the Kremlin, already conveyed the so called grand jury, a citizen’s assembly which will in the best tradition of senator Joe McCharty’s investigations of the anti-American activities, decide – based on the reports of the US intelligence agencies which have until today presented no hard evidence, no “smoking gun”, proving that Moscow really did meddle in the presidential elections – if Trump was elected American president due to the will and support of the American votes (meaning electors), or due to the influence from Moscow.

Judging by the present state of affairs, it is not hard to anticipate their decision.

In the meantime nobody is mentioning any more the financial irregularities (to say the least) in the activity of the Clinton Foundation, or the unprotected e-mails the former Secretary of State sent from an unprotected mobile phone, thus breaking the law (what she, despite the evidence, denied to have done). Nobody is mentioning her role in the ill-fated Arab Spring, especially in the toppling of the Lybian regime and the murder of colonel Ghadafi. On the contrary! The promotion of her hastily written book, entitled “What really happened” is announced, with the clear aim to close the coffin of Trump’s presidency.

And Trump, although being a “foreigner” on the political scene is far from being naïve. He fully understands that it is for him to be or not to be. And he acts like a wounded animal, chased into a corner. He forgets everything he promised during the election campaign (with the exception of the wall along the border with Mexico), he forgets his words that “America will no longer impose the American way of life” on anybody and his politics (if the stumbling from one day into the other can be called politics) resembles more and more those of George W. Bush and Barack Obama (read: Hillary Clinton). And he repeatedly and with ever greater enthusiasm threatens with the American military might, which brought him on the verge of open war with seemingly unpredictable, but in reality very “down to the Earth” regime of North Korea. Kim Yong Un seems to be an enigma to the world, but let us not forget that he was educated in the West. He knows perfectly well whom he is dealing with, while Trump entered the war games without knowing anything about Kim – if we forget the slogans about the harsh dictatorship and the last bastion of communism and what else the military-industrial complex is “feeding” him with in order to always have an enemy, even at the risk of a world war.

Today’s world is on the brink of a confrontation with unforeseeable consequences. But, it is not Donald Trump who is to be blamed for this in the first place. Much more – the system that opened for him the doors of the White House and is now trying- mainly through the activities of the deep state – to throw him out of there. Both things, needless to say: democratically. Because of that, is it not the last minute to start thinking about what is really the system we call democracy and what is this system giving us (or taking from us)? So, it is not Donald Trump we are dealing with, it is democracy, better to say system we view as democracy and which has with the original meaning of the world less and less in common. After all, was it not the 2nd President of the United States, John Adams, who said: “Remember, democracy never lasts long. It soon wastes, exhausts, and murders itself. There never was a democracy yet that did not commit suicide.” And did we remember, do we remember?

**Tomislav Jakić* was Foreign Policy Advisor to former Croatian President Stjepan Mesić Reported by Eurasia Review 41 minutes ago.

↧

Barcelona van attack kills 13 in agonizing repeat for Europe

August 17, 2017, 11:15 pm

≫ Next: Photocat A/S: 2nd Quarter Interim Report 2017

≪ Previous: What We Are Dealing With: Trump Or Democracy – OpEd

A white van plowed into a packed summer crowd Thursday in Barcelona's historic Las Ramblas district, killing some people and... Reported by Deseret News 41 minutes ago.

↧

Photocat A/S: 2nd Quarter Interim Report 2017

August 17, 2017, 11:13 pm

≫ Next: Brunel International NV: H1 2017: Disappointing half year, first signs of recovery

≪ Previous: Barcelona van attack kills 13 in agonizing repeat for Europe

*Main highlights during the second quarter of 2017*

· Signed agreement on May 29th 2017 with S:T Eriks AB, Sweden's leading manufacturer of concrete products.
· As part of the process of establishing a board of directors consisting of mainly independent members both Henrik Jensen and Thomas Becker was replaced by Gitte Haanig-Høj and Theis Reenberg at the annual general meeting in April, the latter representing the major shareholder PhotoC Holding.
· The Danish market for Photocat Garden products experience serious price competition.
· Granted patent for concrete wet technology in EU.
· Lauzon report highest ever sales of its Pure Genius product range which is based on the actiFLOOR technology.
· Developed business offer together with Gammelrand to major Danish cities.
· Binne & Sohn attain and install first NOxOFF reference project in Leipzig.

*Main highlights during the first six months of 2017*

· Signed agreement on May 29th 2017 with S:T Eriks AB, Sweden's leading manufacturer of concrete products.
· La Roda and Adybor attain first orders for NOxOFF products in Spain.
· The Danish market for Photocat Garden products experience serious price competition.
· ASAK A/S, a leading concrete manufacturer in Norway, launches the NOxOFF technology as standard on all "Gangbaneheller".
· Enter into technology partnership with Troldtekt A/S, a leading manufacturer of acoustic ceilings in Europe, for the development of photocatalytic indoor acoustic ceilings.
· Share capital increased with 643.700 shares through a private placement to the company Strategic Investments A/S on February 15th 2017

*Significant events after the second quarter 2017 *

· Secured two new customers in Spain: SAGRA S.A. and Prehorqui S.A.
· Implemented cost alignment programme.
· Successful production test for new indoor acoustic ceiling application in cooperation with Troldtekt A/S, a leading manufacturer of acoustic ceilings in Europe.

*Financial summary*

Amounts in DKK '000s *1 Apr - 30 Jun*
*2017* *1 Apr - 30 Jun*
*2016* *1 Jan - 30 Jun*
*2017* *1 Jan - 30 Jun*
*2016* *Full Year*
*2016***
Revenue from photocatalytic fluid 772.4 1,898.6 2,831.9 3,183.5 4,446.1
Revenue from Consultancy, Equipment & Other 131.1 552.6 1,451.7 791.2 1,188.8
Gross Profit - 888.6 347.3 224.2 170.6 -2,593.9
EBITDA - 2,067.6 - 716.6 - 2,234.9 - 1,818.7 - 7,341.5
P/L before Tax - 2,815.9 - 1,382.5 3,762.6 3,138.5 -9,954.9
Net Profit - 2,640.9 - 1,338.0 - 3,587.6 - 3,028.3 - 9,782.4
Total Assets 18,775.8 23,499.8 18,775.8 23,499.8 16,029.9
Equity 14,938.8 15,963.3 14,938.8 15,963.3 9,209.0
Debt 3,837.0 7,536.5 3,837.0 7,536.5 6,820.9
Cash at Hand 2,874.0 6,278.4 2,874.0 6,278.4 172.4
** Audited

*About Photocat*

Photocat manufactures patented photocatalytic coating materials for outdoor and indoor applications, which degrade NOx and VOCs when exposed to light. Both NOx and VOCs are severely damaging to human health. Photocat's patented technology is very efficient and an economically viable alternative to many of the traditional technologies targeting NOx (e.g. bus catalysts, flue gas cleaning etc.). Photocat's shares are listed on Nasdaq First North Stockholm with the ticker symbol PCAT. The company's certified advisor is Mangold Fondkommission.

*For More Information*

· Please visit our website
· Or contact Adam Sagedahl, Strategic Director at Photocat A/S, at adam.sagedahl@photocat.net or +45 42 75 95 46

Photocat A/S is obliged to publisize this information in accordance with the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at CET 08:00 on August 18th 2017.

2017.Q2 Interim Report
--------------------This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: Photocat A/S via GlobeNewswire

HUG#2127923 Reported by GlobeNewswire 43 minutes ago.

↧

Brunel International NV: H1 2017: Disappointing half year, first signs of recovery

August 17, 2017, 11:13 pm

≫ Next: Asian shares track Wall Street slide; Spain attack weighs

≪ Previous: Photocat A/S: 2nd Quarter Interim Report 2017

Amsterdam, 18 August 2017

*Key points Q2 2017*

· Revenue down by 18% to EUR 189 million
· EBIT down to EUR -1 million

*Key points H1 2017*

· Revenue down by 18% to EUR 385 million
· EBIT down to EUR 5 million

*Brunel International (unaudited)*
P&L amounts in EUR million
*Q2 2017* *Q2 2016* *Change %* *H1 2017* *H1 2016* *Change %*
Revenue 188.9 231.2 *-18%* ^a 385.3 469.6 *-18%* ^b
Gross Profit 39.7 47.7 *-17%* 86.9 95.6 *-9%*
Gross margin 21.0% 20.6% 22.6% 20.4%
Operating costs 40.8 40.2 *2%* ^c 82.4 79.0 *4%* ^d
EBIT -1.2 7.5 *-116%* 4.6 16.6 *-73%*
EBIT % -0.6% 3.2% 1.2% 3.5%

Average directs 9,201 9,336 *-1%* 9,093 9,629 *-6%*
Average indirects 1,496 1,500 *0%* 1,478 1,526 *-3%*
Ratio direct / indirect 6.2 6.2 6.2 6.3

^a -19 % at constant currencies
^b -19 % at constant currencies
^c 2 % at constant currencies
^d 4 % at constant currencies

   * *
*H1 2017 results by division*

*Brunel Global Business (unaudited)*
P&L amounts in EUR million
*Q2 2017* *Q2 2016* *Change %* *H1 2017* *H1 2016* *Change %*
Revenue 81.1 119.8 *-32%* ^a 163.2 248.3 *-34%* ^b
Gross Profit 9.2 13.3 *-30%* 18.7 27.3 *-31%*
Gross margin 11.4% 11.1% 11.5% 11.1%
Operating costs 11.3 12.7 *-11%* ^c 22.7 25.0 *-9%* ^d
EBIT -2.0 0.6 *-446%* -3.9 2.3 *-270%*
EBIT % -2.5% 0.5% -2.4% 0.9%

Average directs 4,418 4,656 *-5%* 4,351 4,911 *-11%*
Average indirects 510 598 *-15%* 507 613 *-17%*
Ratio direct / Indirect 8.7 7.8 8.6 8.0

^a -33 % at constant currencies
^b -36 % at constant currencies
^c- 12 % at constant currencies
^d -12 % at constant currencies

* *
*Key points Q2 2017*

· Revenue down by 32% to EUR 81 million
· Gross margin 11.4%, up from 11.1% last year
· EBIT down by 446% to EUR -2 million


*Key points H1 2017*

· Revenue down by 34% to EUR 163 millionGross margin 11.5%, up from 11.1% last year
· EBIT down by 270% to EUR -4 million

Revenue
Revenue in Q2 decreased by 32% year on year, and 1% compared to Q1. The regions Americas, Middle East and Russia achieved growth compared to Q1, offset by a decline in Australia and South East Asia. In Australia and South East Asia, significant projects were largely completed in the course of Q2. We are working on several initiatives to speed up our diversification. We expect that some of these initiatives will start contributing in the second half of the year.

Gross profit
The gross margin increased slightly as a result of a change in the mix, both across the globe and between activities.

Operating costs
Cost savings in our existing business are partly offset by investments in new initiatives, as a result operating costs in Q2 decreased by 11%.

*Brunel Europe (unaudited)*
P&L amounts in EUR million
*Q2 2017* *Q2 2016* *Change %* *H1 2017* *H1 2016* *Change %*
Revenue 107.8 111.4 *-3%* 222.1 221.3 *0%*
Gross Profit 30.4 34.4 *-11%* 68.2 68.4 *0%*
Gross margin 28.2% 30.9% 30.7% 30.9%
Operating costs 27.3 24.8 *10%* 54.9 49.3 *11%*
EBIT 3.2 9.6 *-67%* 13.3 19.1 *-30%*
EBIT % 3.0% 8.6% 6.0% 8.6%

Average directs 4,783 4,680 *2%* 4,742 4,718 *1%*
Average indirects 934 859 *9%* 921 870 *6%*
Ratio direct / Indirect 5.1 5.4 5.1 5.4


Brunel Europe consists of Brunel Germany, Brunel Netherlands, Brunel Belgium, Brunel Czech Republic, Brunel Switzerland and Brunel Austria.

*Key points Q2 2017*

· Revenue down by 3% to EUR 108 million
· Gross margin 28.2%, down from 30.9% last year
· EBIT down by 67% to EUR 3 million

*Key points H1 2017*

· Revenue up by 1 million to 222 million
· Gross margin 30.7%, down from 30.9% last year
· EBIT down by 30% to EUR 13 million

*Brunel Germany (unaudited)*
P&L amounts in EUR million
*Q2 2017* *Q2 2016* *Change %* *H1 2017* *H1 2016* *Change %*
Revenue 52.0 52.9 *-2%* 108.3 102.5 *6%*
Gross Profit 16.4 18.9 *-13%* 37.3 35.8 *4%*
Gross margin 31.5% 35.7% 34.4% 34.9%
Operating costs 13.5 12.6 *6%* 27.2 24.5 *11%*
EBIT 2.9 6.3 *-54%* 10.1 11.3 *-11%*
EBIT % 5.6% 11.9% 9.3% 11.0%

Average directs 2,274 2,174 *5%* 2,265 2,160 *5%*
Average indirects 423 405 *4%* 412 416 *-1%*
Ratio direct / Indirect 5.4 5.4 5.5 5.2

Revenue
On 1 April, the new law came into effect and to comply we had to renew our union trade agreement. Some of our customers have suspended us as supplier until we had our new union trade agreement in place, what caused a temporary hiccup in the growth. We finalized the renewal at the end of July. This renewed agreement offers us a strong competitive advantage. Revenue per working day increased by 3%. Headcount at 30 June 2017 is 3% above last year's headcount.

Working days

Q1 Q2 Q3 Q4 FY
2017 65 59 65 60 249
2016 62 62 66 62 252

Gross Profit
Gross margin adjusted for working days is 34.8% (2016: 35.7%). Additional price pressure is mainly due to volumetric customers.

Operating costs
Operating costs in H1 increased with 11% mainly driven by strengthening the commercial organization to facilitate further growth.


*Brunel Netherlands (unaudited)*
P&L amounts in EUR million
*Q2 2017* *Q2 2016* *Change %* *H1 2017* *H1 2016* *Change %*
Revenue 46.6 49.2 *-5%* 94.5 100.9 *-6%*
Gross Profit 12.3 13.4 *-9%* 26.6 28.5 *-6%*
Gross margin 26.3% 27.3% 28.2% 28.2%
Operating costs 11.6 10.2 *14%* 23.5 20.7 *13%*
EBIT 0.6 3.2 *-81%* 3.2 7.7 *-59%*
EBIT % 1.3% 6.5% 3.3% 7.6%

Average directs 2,181 2,173 *0%* 2,153 2,224 *-3%*
Average indirects 437 381 *15%* 437 381 *15%*
Ratio direct / Indirect 5.0 5.7 4.9 5.8

Revenue
The revenue development is a mix of a decline in freelancers (impact -10%) and growth in own employees (impact +5%). Q2 2017 had one less working day compared to last year. Revenue per working day decreased by 4%. The growth in Engineering and Legal is more than offset by the decline in the other business lines. Headcount at 30 June 2017 is 2% above last year's headcount.

Working days

Q1 Q2 Q3 Q4 FY
2017 65 61 65 63 254
2016 63 62 66 64 255

Gross Profit
The gross margin adjusted for working days is 27.5% (2016: 27.3%). The increase in gross margin due to the change in mix is largely offset by a lower productivity.

Operating costs
The operating costs increased due to continuous investment in sales force and technology.
* *
*Effective tax rate*
The effective tax rate in the first half year of 2017 is 75.6%. Due to the seasonality in Europe our tax rate is higher in the first half of the year. For the full year, we project the effective tax rate to come down significantly.

*Risk profile*
Reference is made to our 2016 Annual Report (pages 57 - 75). Reassessment of our earlier identified risks and the potential impact on occurrence has not resulted in required changes in our internal risk management and control systems.

*Cash position*
Brunel's cash position decreased to EUR 127 million, due to the seasonality and the dividend payment in June.

*Outlook for 201* *7*
The Netherlands will return to revenue growth from Q3 onwards, and Germany will continue to grow. For Global Business we expect revenue to remain flat for the next couple of months until the impact of our initiatives becomes visible. There is some uncertainty around the timing of the first revenues from these initiatives, but we expect to achieve an EBIT of at least EUR 15 million for the full year.

Jan Arie van Barneveld, CEO of Brunel International N.V.: " We knew the first half year would be tough, but we have reached the bottom of the trough sooner than expected. Our actual performance has been improving day by day. With Europe on a growth track, and all the initiatives in Global Business, I'm confident that we will return to sustainable growth pretty quickly"

*Statement of the Board of Directors*
The Board of Directors of Brunel International N.V. hereby declares that, to the best of its knowledge, the interim financial statements give a true and fair view of the assets, liabilities, financial position and result of Brunel International N.V. and the companies jointly included in the consolidation, and that the interim report gives a true and fair view of the information referred to in the eighth and, insofar as applicable, the ninth subsection of Section 5:25d of the Dutch Act on Financial Supervision and with reference to the section on related parties in the interim financial statements.

Amsterdam, 18 August 2017
Brunel International N.V.

Jan Arie van Barneveld (CEO)
Peter de Laat (CFO)

Brunel Q2 and H1 2017 results
Brunel Q2 and H1 2017 appendix
--------------------This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: Brunel International NV via GlobeNewswire

HUG#2127910 Reported by GlobeNewswire 43 minutes ago.

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Asian shares track Wall Street slide; Spain attack weighs

August 17, 2017, 11:16 pm

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HONG KONG (AP) — Asian stocks sank Friday as global investor sentiment was battered by big losses on Wall Street amid U.S. political turmoil and a deadly van attack in Spain. KEEPING SCORE: Japan's benchmark Nikkei 225 index lost 1.2 percent to 19,468.05 and South Korea's Kospi shed 0.2 percent to 2,358.14. Hong Kong's Hang Seng sank 0.6 percent to 27,184.18, coming off lows earlier in the session, while the Shanghai Composite index reversed losses, edging up 0.1 percent to 3,271.36. Australia's S&P/ASX 200 fell 0.6 percent to 5,742.80. Taiwan's benchmark also fell and Southeast Asia indexes were mostly lower. BARCELONA ATTACK: Investors shied away from riskier investments following the latest attack to hit Europe. Reported by SeattlePI.com 40 minutes ago.

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Hacking Hotels And Their Guests – Analysis

August 17, 2017, 11:56 pm

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By Lawrence Husick*

(FPRI) — Travelers have come to depend on WiFi networks in hotels, and businesspeople have come to expect high speed wireless access in both private rooms and public spaces, including lobbies, meeting rooms, and even the hotel gym.

Predictably, cyberspies and cybercriminals have inhabited some of these virtual spaces as well. Hotel lobbies are often seen to sprout open networks with identifiers intended to trick users into logging on. (“FreeOpenWiFi,” “Hilt0n,” and “MarriottL0BBY” have all been seen in the past month.) Security firm FireEye, however, has recently documented a new and more dangerous threat in the hotel space: a hacking campaign attributed to the Russian government sponsored, GRU-affiliated group known as “Fancy Bear” or “APT28.” (One of the two Russian groups known to have penetrated the Democratic National Committee in 2015-6.) This campaign, evident in hotels in Europe and the Middle East, is potentially more dangerous than prior exploits, and may spread rapidly to other regions. Travelers need to be aware of the dangers, and need to take immediate steps to protect sensitive information.

The activities of these Russian-sponsored hackers are widespread and sophisticated. The name “APT” is an abbreviation of “Advanced Persistent Threat,” and is the term used in the cybersecurity community to denote an actor that is especially thorough and patient in the infiltration of computer systems and exfiltration of information. Fancy Bear has been implicated in cyber attacks against the World Antidoping Agency, the Dutch government, and against political parties in this year’s French and German elections. Information stolen in these hacks has been distributed through WikiLeaks, other web sites, and by transmitting it to media outlets such as Sputnik, RT, and others.

Briefly, the new campaign is initiated by an email “spearphishing” campaign using an attached document that appears to be a room reservation form in a Microsoft Word document file. Once opened by hotel staff, that document installs malware onto the target Windows computer that then uses exploits stolen from the U.S. National Security Agency (EternalBlue) to move laterally to infect other computers in the target network.

The malware, known as GAMEFISH, is capable of stealing logon credentials and other information from the network, and communicating this information over the internet to command and control servers controlled by unknown actors. Because GAMEFISH can attack the very computers that control the hotel wireless network, it may be able to steal information from guest computers simply using that network, even if those computers are never directly attacked or compromised. This information may then be used to attack the guest computers directly, perhaps even at a remote location and time.

This threat is by no means the only hotel-based hacking to be seen. For some time, networks in Russian and Asian hotels have been infected with computer worm and virus files of various types. During the Iranian nuclear talks in 2014-15, Duqu 2.0 malware was seen in the networks of the hotels that hosted the delegations and the talks themselves. It was believed that Duqu was an information stealing worm, capable of turning on computer microphones and cameras covertly, as well as stealing computer files. According to the Guardian, this worm is related to Stuxnet, and was thought to be used by the government of Israel as a way of gaining intelligence about the nuclear negotiations.

Because guests cannot be sure that hotel systems have not been compromised, it is advisable that such systems be avoided if possible, in favor of data carried over cellular networks which, while not immune to attack, are at least monitored more closely than commercial wireless systems in hotels. Even then, care should be exercised, and secure communications should be avoided because it is not possible to guarantee the security of cellular communications. Governments use devices called “stingrays” to intercept cellular signals. Not only can they listen to voice communications, but they are able to see text messages and in some instances, spy on data communications as well. While the sale and use of stingray devices is severely restricted in the United States, the same cannot be said for the rest of the world, and thus, care is necessary.

If a hotel network must be used, access should only be through a virtual private network (VPN), preferably one that is operated under private and trusted control, or a reputable commercial service. Virtual Private Networks are a type of data transmission service that ensures that all data flowing from a secured device goes only to a known computer system, and is encrypted from “end-to-end” as it flows to and from that trusted system. Once the encrypted information reaches the trusted VPN “server,” it may then be forwarded onward over the internet, if the VPN is configured to do so. In this manner, the VPN impedes eavesdropping on data communications because the secure link is the first thing set up during an online session.

For more information about commercial VPN services, see https://www.pcmag.com/article2/0,2817,2403388,00.asp

We all seem to depend more every day on the electronic devices in our pockets and bags, and we carry ever-greater amounts of personal and business information in them. Governments and criminals know this, as well, and have set traps for the unwise and the unwary. Hotels are just the latest venues made dangerous for us and our data. The savvy traveler will now ask, first and always, whether access to a particular system is really worth the risk involved, if it must be done over connections that are likely to have been compromised. It may be better, after all, to forego checking one’s accounts, and just to relax and have an aperitivo.

*About the author:
*Lawrence Husick* is Co-Chairman of the Foreign Policy Research Institute’s Center for the Study of Terrorism where he concentrates on the study of terrorist tactics and counterterrorism strategies, with a particular focus on technology leverage as a defining characteristic of the modern terrorist. He is also co-director of the FPRI Wachman Center’s Program on Teaching Innovation and a faculty member at the Whiting Graduate School of Engineering and the Krieger School of Arts and Sciences Graduate Biotechnology Program of the Johns Hopkins University.

*Source:*
This article was published by FPRI Reported by Eurasia Review 17 seconds ago.

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AIR FRANCE - KLM: Availability of the prospectus relating to the capital increases reserved to China Eastern Airlines and Delta Air Lines

August 17, 2017, 11:38 pm

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Paris, on 18 August 2017

*Availability of the prospectus relating to the capital increases reserved to China Eastern Airlines and Delta Air Lines*

Air France-KLM (the « Company ») announces that the prospectus relating to the Company's capital increases without preferential subscription rights, for a total amount of EUR 750,548,200 (including share issue premium), has been approved by the French Financial Markets Authority ( Autorité des marchés financiers ), on 17 August 2017, under number 17-441. Such capital increases are reserved to China Eastern Airlines and Delta Air Lines in the context of the strengthening of the group's strategic partnerships announced on 27 July 2017.

The prospectus includes:

-           the Company's registration document ( document de référence ), filed with the Autorité des marchés financiers (the « AMF ») on 31 March 2017 under number D.17-0287;
-           the update to the registration document filed with the AMF on 17 August 2017 under number D.17-0287-A01;
-                       a securities note ( note d'opération ); and
-                       a summary of the prospectus (included in the securities note).

The French language Prospectus is available free of charge from the Company at its registered office as well as from the website of the Company ( www.airfranceklm.com/finance ) and of the AMF ( www.amf-france.org ). An English translation is also available on the Company's website.

The Company draws the public's attention to the risk factors included in Chapter 3 of the registration document, Chapter 6 of the update to the registration document and Chapter 2 of the securities note.

* About Air France-KLM *

Air France-KLM is the air transport leader in terms of international traffic on departure from Europe. In 2016, it offered customers a network covering 320 destinations across 114 countries, thanks to its four brands, Air France, KLM Royal Dutch Airlines, Transavia and HOP! Air France. With a fleet of 534 aircraft in operation and 93.4 million passengers carried in 2016, Air France-KLM operates up to 2,200 flights a day, principally on departure from the Group's Paris-Charles de Gaulle and Amsterdam-Schiphol hubs.

Its Flying Blue frequent flyer program ranks amongst the leaders in Europe and numbers more than 27 million members.

With its partners Delta Air Lines and Alitalia, Air France-KLM operates the largest trans-Atlantic joint-venture with 270 daily flights.

Air France-KLM is also a member of the SkyTeam alliance bringing together 20 airlines and offering access to a global network of more than 16,270 daily flights to 1,057 destinations in 179 countries.

* Disclaimer *

This press release does not and shall not be considered as an offer to the public, an offer to sell or to subscribe or aimed at soliciting a purchase or subscription order in any jurisdiction.

No communication and no information in respect of this transaction may be distributed to the public in any jurisdiction where a registration or approval is required. No steps have been or will be taken in any jurisdiction where such steps would be required. The issue, the subscription for or the purchase of Air France-KLM's shares may be subject to specific legal or regulatory restrictions in certain jurisdictions. Air France-KLM assumes no responsibility for any violation of any such restrictions by any person.

This press release does not constitute an offer or incitation to sell or purchase, or a solicitation of any offer to purchase or subscribe for, any securities of Air France-KLM in the United States of America. Securities may not be offered, subscribed or sold in the United States of America absent registration under the U.S Securities Act of 1933, as amended (the "U.S Securities Act"), except pursuant to an exemption from, or in a transaction not subject to, the registration requirement thereof. The securities of Air France-LKM have not been and will not be registered under the U.S Securities Act and Air France-KLM does not intend to make a public offer of its securities in the United States of America.

AFKLM: Availability of a prospectus
--------------------This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: AIR FRANCE - KLM via GlobeNewswire

HUG#2127919 Reported by GlobeNewswire 18 minutes ago.

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Spanish police kill 5 suspects linked to Barcelona attack

August 17, 2017, 11:40 pm

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Spanish police have shot and killed five people carrying bomb belts who were connected to the Barcelona van attack that killed 13 people, as the manhunt intensified for the perpetrators of Europe's latest rampage claimed by the Islamic State group. Reported by DNA 16 minutes ago.

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Barcelona attack suspect still sought as investigation expands to other countries

August 20, 2017, 9:30 pm

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Spanish police searched on Sunday for the man behind the wheel in the Barcelona van attack that killed 13 people, amid growing signs members of the militant group had connections elsewhere in Europe. Reported by DNA 3 hours ago.

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City Moves for 21 August 2017 - who's switching jobs?

August 20, 2017, 9:17 pm

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City Moves for 21 August 2017 - who's switching jobs?

Today's City Moves cover digital strategy, asset management and trading technology. Take a look at these movers and shakers:

*Manifesto*

Digital agency Manifesto has appointed two new senior hires who will help the agency grow its strategy team while continuing to deliver its superior customer service. Phil Aiston (pictured) joins as client strategist, responsible for developing Manifesto’s digital media and strategy offering. Phil brings nearly five years of digital marketing experience to Manifesto, having worked both client and agency side to create scalable strategies for large retail networks. Phil will be using this knowledge to assist the acquisition and engagement strategies of a wide range of organisations across social, email and paid digital media. Vaughan Johnstone joins as account director. After more than six years advising and supporting clients on the role of digital, Vaughan joins Manifesto from digital communications company Investis, where he worked with a number of FTSE 100 companies. Vaughan also has experience of the housing sector, which will be applied to Manifesto’s ongoing work with housing associations.

*Legg Mason*

Alexander Barry has been appointed head of UK sales at Legg Mason, one of the world’s largest active asset management firms. Alexander will be based in London and will start today. He will report to Justin Eede, head of Europe and Americas distribution at Legg Mason. Alexander will lead Legg Mason’s distribution of a range of actively managed, UK and Dublin-domiciled equity, fixed income and alternative investment funds to the UK wholesale and institutional market. He joins from JP Morgan Asst Management, where he spent nearly 20 years in various sales positions, most recently as senior relationship manager for global strategic relationships. Previous positions include head of UK asset manager sales, where he was responsible for key client relationships with wealth managers, banks and fund of funds as well as head of retail sales in the UK.

*Liquidnet*

Liquidnet, the global institutional trading network, has announced the appointment of Patrick Strobel as head of technology for EMEA. In this newly formed role, Patrick will be responsible for building out Liquidnet’s strategic IT architecture in EMEA with an emphasis on the region’s Virtual High Touch Mifid II solutions. He brings more than 16 years of experience delivering IT solutions for investment banks such as Deutsche Bank and JP Morgan. At Deutsche Bank, Patrick held a number of senior roles, including head of IPV technology, as well as global head of equity trading analytics. He was responsible for building out Deutsche’s P&L reporting platform and defining the technology strategy for the domain.

The embedded content could not be displayed. Please go to the article to view this content. Reported by City A.M. 3 hours ago.

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United States retain Solheim Cup

August 20, 2017, 9:36 pm

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The United States recorded their biggest victory over Europe in two decades and continued their near invincibility on home soil to retain the Solheim Cup in Iowa on Sunday. Reported by SuperSport 3 hours ago.

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Global News: Global Electron Microprobe Analyser Market Research Report 2017 - 2021

August 20, 2017, 9:48 pm

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Electron Microprobe Analyser Report by Material, Application, and Geography – Global Forecast to 2020 is a professional and in-depth research report on the world’s major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China). Get complete report @ http://www.gosreports.com/global-electron-microprobe-analyser-market-research-report-2017/ The report firstly introduced the Electron Microprobe Analyser basics: definitions, classifications, applications and market overview, product specifications, manufacturing, processes, cost structures, market size, market... Reported by WorldNews 3 hours ago.

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Gold trades little changed as investors focus on geopolitics, central bank meet

August 20, 2017, 10:27 pm

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BENGALURU (Reuters) - Gold prices were little changed on Monday as investors sought further direction after a week of geopolitical uncertainty in the United States and Europe and ahead of a meeting of central bankers later this week. Reported by Reuters India 2 hours ago.

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Solar Eclipse 2017: What is it, how to watch, where to watch and everything else

August 20, 2017, 11:25 pm

≫ Next: Brendan Rodgers can take Celtic beyond the Champions League group stage says Barcelona icon Xavi

≪ Previous: Gold trades little changed as investors focus on geopolitics, central bank meet

Today is like the Super bowl of the Solar system in North America! On August 21, starting 2:45PM Eastern Time, all of North America will be treated to a total eclipse of the sun. This will be the first total solar eclipse visible in the continental United States in 38 years. Beside everyone in North America, parts of South America, Africa, and Europe will see at least a partial solar eclipse, while the thin path of totality will pass through portions of 14 states. Unfortunately, it will be a regular Monday morning in India, and other neighboring Asian countries. While the sun and moon will cross paths in the Indian skies too, it is estimated to last between 9.15PM to Reported by BGR India 1 hour ago.

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Brendan Rodgers can take Celtic beyond the Champions League group stage says Barcelona icon Xavi

August 20, 2017, 10:23 pm

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≪ Previous: Solar Eclipse 2017: What is it, how to watch, where to watch and everything else

Former Nou Camp legend reckons the Hoops are good enough to join Europe's elite in the knockout stages after Christmas. Reported by Daily Record 2 hours ago.

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