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Inspirata Announces Agreement with Swiss Hospital, Kantonsspital Aarau for the Next-Generation of its Digital Pathology Software to Support a 100% Digital Workflow

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The large public health facility located in the region of Aarau, Switzerland manages more than 350,000 surgical pathology slides in its pathology department each year.

Bilbao, Spain, Sept. 10, 2018 (GLOBE NEWSWIRE) -- Cancer informatics and digital pathology workflow solution provider Inspirata® Europe, Ltd. announced today that it has signed an agreement with Kantonsspital Aarau (KSA) to upgrade to Inspirata’s latest version of Dynamyx™ digital pathology software. An early adopter of the Omnyx® digital pathology solution for clinical use in 2013, the hospital is implementing a 100 percent digital workflow using the next-generation solution from Inspirata.
Kantonsspital Aarau is one of Switzerland’s premier hospitals and has a rich history of offering state-of-the-art, innovative healthcare services. Their decision to digitize the pathology workflow stems from a commitment to provide the best quality of care to its patient population. With digital pathology, the hospital aims to connect remote sites with the centralized pathology laboratory, enable faster access to previously digitized slides and prior patient information, support and improve multidisciplinary team discussions and enhance patient care.

Specific upgrades include deeper integration with the Laboratory Information Management Systems (LIMS), external case sharing and collaboration on cases, adding fluorescence to the digital workflow and moving from a single-use-case scanner to scanners capable of supporting every use case in surgical pathology.

“The next-generation Dynamyx software is a powerful solution that has capability to ingest images from a wide range of scanners. This will enable us to meet our goal having a 100 percent digital workflow,” says KSA’s Chief Pathologists Professor Rainer Grobholz. “But it goes much further than that by providing efficiency-enhancing tools that save time and help us provide faster results to our patients.”

 “As part of this engagement, Inspirata will be providing multiple scanners along with the latest version of Dynamyx to support KSA’s goals related to being a leader in digital pathology and providing outstanding patient care,” says, General Manager, Inspirata Europe, Ltd., Tim Wing.

*About KSA *

Kantonsspital Aarau (KSA) is the largest hospital in the canton of Aargau and, next to the university hospitals, one of the largest center hospitals in Switzerland. Since 2010, the Department of General Internal Medicine has been awarded the status of a university clinic. As a trans-regional health center, KSA has a first-class medical-technical infrastructure, is active in research and is an important education center for aspiring medical specialists as well as an attractive employer for numerous occupational groups through the training of 31 specialist titles, 19 of them A-status across care, therapy and operation.

*About Inspirata, Inc.*

Inspirata^®, Inc. provides oncology diagnostics workflow solutions that span digital pathology; diagnostic and predictive assays; and precision medicine. It also offers cancer informatics workflows that, in combination with its Natural Language Processing (NLP) and Artificial Intelligence (AI) algorithms structures unstructured case files and clinician notes to provide key insights for oncology-specific clinical and operational activities as well as cancer reporting. Inspirata’s flagship solution is its Cancer Information Data Trust (CIDT) that generates a longitudinal view of oncology patients—from diagnosis, through treatments and therapies, to outcomes. The CIDT has extensive applications in clinical decision support, research, education, drug discovery and clinical trials enrollment. Its use will extend to physicians, patients, researchers, pharma and others. For more information, please visit www.inspirata.com or contact info@inspirata.com.

*Attachment*

· KAS

CONTACT: Marjorie Bulone
Inspirata, Inc.
813-570-8905
mbulone@inspirata.com

Graeme Collins
Inspirata Europe, Ltd.
+44 (0)7854 664168
gcollins@inspirata.com Reported by GlobeNewswire 3 hours ago.

Forex Today: A quiet start to a busy week ahead, UK GDP in focus

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Forex today stuck today to thin trading ranges in Asia this Monday, marking for a dull start to a brand new week, as investors preferred to stay on the sidelines heading into a week full of central banking action. Hence, rising Chinese inflation and upbeat Japanese growth figures failed to impress the markets.

Amongst the Asia-pac currencies, the Yen traded better bid below 111.00 versus the US dollar amid moderate risk-aversion, as worries over US tariffs on Japan and China continue to loom. Meanwhile, the Kiwi tumbled following the sell-off in the Chinese equity markets and after the latest NZIER Consensus Forecasts expected a slight downward revision to the growth outlook for the next two years. The gains in the Aussie remained capped below 0.7120 level, in the wake of ongoing EM turmoil and mixed commodities prices.

Among other related news, Sweden headed for a hung parliament after Sunday’s election that saw support for the nationalist Sweden Democrats surge, as one of Europe’s most liberal nations turned right amid fears over immigration.

*Main topics in Asia*

EU to give Barnier mandate to close Brexit deals - Financial Times

As reported by the Financial Times, new instructions for the European Union's chief Brexit negotiator, Michel Barnier, are expected in soon to begin extending an olive branch to the UK's Prime Minister, Theresa May. 

China's trade surplus with US rose to new record high in August

China's trade surplus with the US as represented by the gap between the exports and imports rose to new record highs in August, the official data released over the weekend showed. 

China's CPI accelerates to 0.7% m/m in August, beats estimates

According to the latest data published by China’s the National Bureau of Statistics (NBS), the Chinese Consumer Price Index (MoM) (August) came in at +0.7% vs +0.5% exp and +0.3% last, while Consumer Price Index (YoY) (August) 2.3% vs 2.2% exp and 2.1% last.

Japan PM Abe: Trade fights do not benefit any country

Japanese PM Shinzo Abe was on the wires last hour, via Reuters, noting that trade fights do not benefit any country.

Japan PM Abe: Want to increase consumption tax as planned

Japan’s PM Abe is back on the wires now, via Reuters, noting that he wants to increase consumption tax as planned.

China's State Council Committee on financial stability: To fend off "black swan" events

Reuters reports key highlights from a statement issued by China's State Council Committee on financial stability, in light of any Black Swan events.

Italy’s EcoMin Tria: Italian bond yield spread to fall as government starts to act

Speaking at a business conference on the shores of Lake Como on Sunday, the Italian Economy Minister Giovanni Tria noted that his government plans to implement new fiscal policies to spur the economic growth …

RBA’s Bullock sees vulnerability from high household debt

Michele Bullock, Reserve Bank of Australia’s (RBA) Assistant Governor for Financial System is out on the wires now, via Reuters, making her scheduled speech titled "The Evolution of Household Sector Risks" at an Australian Industry Group event, in Albury.

Fed’s Rosengren: No need to quicken pace of rate hikes

Reuters is out with the latest comments from Boston Federal Reserve (Fed) President Eric Rosengren, with the key headlines …

EUR/SEK Technical Analysis: Downside calling, Sweden faces the risk of a hung parliament

Sweden is facing a risk of political deadlock after the far-right Sweden Democrats party put on a good show in Sunday's elections. Still, the EUR/SEK technical chart is biased toward the bears, meaning the Swedish Krona (SEK) is likely to appreciate.

*Key Focus ahead*

The EUR calendar for this week remains quite eventful, with Monday kicking-off with the UK data dump, with the monthly GDP figures to be closely watched among the trade and industrial production releases. The UK July GDP, due at 0830 GMT, is expected to arrive at 0.3% versus 0.1% previous while the manufacturing numbers are seen declining across the time horizon for July. For the Euroland, the August Sentix investor confidence gauge will be reported at the same time. Besides, the FOMC member Bostic’s speech is scheduled ahead of the US open at 1200 GMT.

Meanwhile, the NA session offers nothing of relevance in terms of macro news, as Brexit and trade-related developments will continue to drive the market sentiment.

EUR/USD: Risks are skewed to the downside

For *EUR/USD*, the path of least *resistance* is to the downside. The 5-day and 10-day moving averages (MAs) are trending south, indicating a bearish setup. Meanwhile, 14-day relative strength index (RSI) has adopted a bearish bias.   

GBP/USD sees Brexit hopes rising as UK GDP rounds the corner

The GBP/USD is continuing to hold steady just above the 1.2900 level after the pair wound up middling near the technical handle through last week, and renewed hopes for a passable Brexit deal are about to face down Monday's GDP reading for the UK economy.

Gold Technical Analysis: Deeper losses likely below key support of $1,189

Gold has established a lower highs pattern, as seen in the hourly chart below, and a break below $1,189 (Sep. 4 low) would establish a  lower pattern and open the doors to re-test of Aug. 18 low) and $1,160 (Aug. 16 low).

Key events for the week ahead: ECB and BoE policy decision on the cards - Nomura

Analysts at Nomura offered their outlook for this week's key scheduled events.

Week of September 10 - In EM contagion is raging - TDS

Analysts at TD Securities, (TDS), explained that the word "contagion" is increasingly being used to explain the broad-based poor performance of EM assets. 

  Reported by FXstreet.com 3 hours ago.

Fast Europe Open: UK manufacturing output, Turkey GDP

President Juncker, give towns and regions the support that Europe needs!

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Europe faces massive challenges, from migration to climate change and all points between. As Jean-Claude Juncker gears up to make his final address to this European Parliament, Frédéric Vallier calls on the Commission boss not to forget the role of cities and regions. Reported by EurActiv 3 hours ago.

Sensorion to Partner with Vestibular Disorders Association (VeDA) in Sponsorship of Balance Awareness Week 2018 for Vestibular Disorders

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MONTPELLIER, France, Sept. 10, 2018 (GLOBE NEWSWIRE) -- *Sensorion** (**FR**0012596468 – **ALSEN**), *a biotech company specializing in the treatment of inner ear diseases, today announces that it has joined with the Vestibular Disorders Association (VeDA) to help educate the public and raise awareness of balance and vestibular disorders on the occasion of the Balance Awareness week, which takes place this year for September 16 to 22. “It is distressing to imagine waking up unsteady and disoriented because of a vestibular disorder affecting the senses,” said Nawal Ouzren, CEO of Sensorion. “It is critical that industry leaders and organizations like VeDA make a concerted effort to spread awareness of these conditions. Like in so many other disease areas, awareness and education are key to bringing the community closer to developing therapeutic solutions for patients struggling with vestibular disorders.”

This month, Sensorion and VeDA are calling for the vestibular community to come together in an effort to amplify a collective push for public support. The goal of this program is to make “vestibular” a household term so that patients can be more quickly and more efficiently diagnosed, effectively treated and can receive the care and support that they need from doctors, friends, family and co-workers. By working with VeDA, Sensorion strives to help advance the funding, research and policymaking needed to positively impact the lives of the thousands of people living with vestibular disorders and balance issues.

More than one-third of adults 40 and older around the globe suffer from the debilitating acute symptoms and chronic imbalance associated with a vestibular disorder, especially those with acute unilateral vestibulopathy (AUV). AUV is the disease focused on by Sensorion’s lead clinical development candidate SENS-111 (Seliforant) and is a debilitating disorder which causes severe vertigo, nausea, and loss of balance with chronic functional deficits for a majority of patients.

*About Balance Awareness Week *

VeDA pioneered Balance Awareness Week in 1997 in order to come together each year and shine a light on these otherwise invisible balance disorders. If we’re all more aware, then we can better understand and be empathetic to those who need our support the most—our family, friends, co-workers, and neighbors. While many of these balance disorders are incurable, faster and more accurate diagnosis, along with effective coping strategies, can greatly improve quality of life. Join us this September for Balance Awareness Week and Fall Prevention Week, and together we can pave the way toward restoring a life rebalanced.

*About Sensorion *

Sensorion is a biotech company pioneering novel treatments of inner ear diseases such as severe vertigo, tinnitus or hearing loss. Two products are currently in the clinical development stage: SENS-111 (Seliforant), in phase 2 in acute unilateral vestibulopathy (vestibular neuritis), and SENS-401 which will enter in Phase 2 in sudden sensory hearing loss. The company was founded by Inserm (the French Institute of Health and Medical Research) and is utilizing its pharmaceutical R&D experience and comprehensive technology platform to develop first-in-class easy-to-administer, notably orally active, drugs for treating and preventing hearing loss and the symptoms of bouts of vertigo and tinnitus.

Based in Montpellier, Southern France, Sensorion has received financial support from Bpifrance, through the InnoBio fund, and Inserm Transfert Initiative.

Sensorion has been listed on the Euronext Growth Paris exchange since April 2015.

www.sensorion-pharma.com

*Contacts*

*Sensorion  *
Nawal Ouzren
CEO
contact@sensorion-pharma.com  
Tél : 04 67 20 77 30 *Investor Relations – International*
*LifeSci Advisors LLC *
Chris Maggos - Managing Director, Europe
chris@lifesciadvisors.com
Tél. : +41 79 367 6254
 

Label : *SENSORION*
ISIN : *FR0012596468*
Mnemonic : *ALSEN*

* *  

*Relations Presse*
*Alize RP*
Caroline Carmagnol & Wendy Rigal
sensorion@alizerp.com

 
   

*Disclaimer*
This press release contains certain forward-looking statements concerning Sensorion and its business. Such forward-looking statements are based on assumptions that Sensorion considers to be reasonable. However, there can be no assurance that such forward-looking statements will be verified, which statements are subject to numerous risks, including the risks set forth in the Document de référence registration document filed with the Autorité des marchés financiers (AMF- French Financial Market Authority) on September 6, 2017 under n°R.17-062 and to the development of economic conditions, financial markets and the markets in which Sensorion operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Sensorion or not currently considered material by Sensorion. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Sensorion to be materially different from such forward-looking statements.

This press release and the information that it contains do not constitute an offer to sell or subscribe for, or a solicitation of an offer to purchase or subscribe for, Sensorion shares in any country. The communication of this press release in certain countries may constitute a violation of local laws and regulations. Any recipient of this press release must inform oneself of any such local restrictions and comply therewith. Reported by GlobeNewswire 3 hours ago.

Heijmans preferred candidate for Main Contract Schiphol runway sites

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*Heijmans has been selected as the preferred candidate for the Runway Sites Parcel of Schiphol's Main Contracts 2019 tender. The contract focuses on maintenance, as well as on the development of existing infrastructure and facilities associated with the runway sites. The initial term of the contract is three years, with an option to extend the contract for two terms of three years. The indicative annual revenue associated with this parcel is 47 million euros. *

Previously the preferred candidate for this parcel could not be announced due to an ongoing appeal procedure filed by another party. This procedure has since been completed. The parcel includes all infrastructure and facilities on and surrounding the runways, including taxiways, service roads, signs and lighting. The infrastructure operations of Heijmans have been active in this area under contract to Schiphol since 2011. Heijmans had already been selected as the preferred candidate for the Terminal 1 & 2 Parcel, including the associated piers. As such, Heijmans is now entering the tender's final phase with two parcels. The proposed plans will be worked out in further detail over the coming months and will then be reviewed with Schiphol. If Schiphol considers the final plans suitable, the contracts are expected to be signed by the end of 2018, with the contract implementation start-up date planned for April 2019.

On successful completion of both processes, Heijmans' overall role at Schiphol will increase. The volume of Heijmans' infrastructure activities at Schiphol, which will be slightly lower with the new contract than under the current contract, will be more than offset by the new contract related to the building & technology activities.

*Main Contracts 2019*
Schiphol initiated a European tender under the name 'Main Contracts 2019' for the purpose of selecting permanent partners for the six parcels for the construction, renovation and maintenance of the infrastructure. The strategic partnerships are negotiated for a maximum of nine years.

Schiphol's ambition to be Europe's Preferred Airport was decisive in the evaluation of the submitted tenders. This is why the emphasis in the tender was on cost optimisation, improving business operations, increasing sustainability and applying digital and other innovations. The construction firms are remunerated on a performance-oriented basis. Their performance ultimately also determines the final remuneration of each firm and their share in the realisation of the project portfolio.

*About Heijmans  *
Heijmans is a listed company that combines activities related to property development, building & technology, roads and civil engineering in the areas living, working and connecting. Our constant focus on quality improvements, innovation and integrated solutions enables us to generate added value for our clients. Heijmans realises projects for private consumers, companies and public sector bodies, and together we are building the spatial contours of tomorrow. You will find additional information at our website: www.heijmans.nl.For more information / not for publication:

Media
Marieke Swinkels-Verstappen
Communications
+31 73 543 52 17
mswinkels-verstappen@heijmans.nl

Analysts
Guido Peters
Investor Relations
+ 31 73 543 52 17
gpeters@heijmans.nl Reported by GlobeNewswire 2 hours ago.

Global Food Processing Equipment Market Will Reach USD 80.27 Billion By 2024: Zion Market Research

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According to the report, the global food processing equipment market was valued at around USD 50.98 billion in 2017 and is expected to reach approximately USD 80.27 billion by 2024, growing at a CAGR of around 7.0% between 2017 and 2024.

New York, NY, Sept. 10, 2018 (GLOBE NEWSWIRE) -- Zion Market Research has published a new report titled *“Food Processing Equipment Market By Equipment Type (Mixers, Depositors, Refrigeration, Slicers And Dicers, Thermal Equipment, Extruding Machines, And Others) and by Application (Dairy Sector, Fisheries, Meat And Poultry, Fruits And Vegetables, Bakery And Confectionery): Global Industry Perspective, Comprehensive Analysis And Forecast, 2017 – 2024”*. According to the report, the global food processing equipment market was valued at around USD 50.98 billion in 2017 and is expected to reach approximately USD 80.27 billion by 2024, growing at a CAGR of around 7.0% between 2017 and 2024.

Global food processing equipment market is primarily driven by changing people’s taste, preference, and food habits growing large consumer base, easily available raw materials, increasing net income of the population, and a broad range of food items. Moreover, rising demand for packaged food products in the developing countries such as China and India with above 1.3 billion population has raised the demand for the food. In addition to this, busy lifestyle and lack of time has increased the dependency on processed food. Thus, rising demand for food has also led to having increased the number of manufacturers in the food & beverage industry, which eventually affects the global food processing equipment market in a positive way. 

*Browse through 37 Tables & 22 Figures spread over 110 Pages and in-depth TOC on “Global Food Processing Equipment Market: Size, Trends, Industry Share, Uses, Manufacturers, Analysis and Forecast, 2015 – 2021”.*

*Request Free Sample Report of Global Food Processing Equipment Market Report @* https://www.zionmarketresearch.com/sample/food-processing-equipment-market

Furthermore, the global food processing equipment market is determined by the other key factor such as growing demand for the dairy, meat & poultry, and seafood products across the world. Besides, raising awareness regarding the safety and quality of food products have led to the increased adoption of the advanced technology and equipment by manufacturers, which are ultimately boosting the global food processing equipment market over the forecast period. For instance, on 1st March 2017, The Bühler Holding AG introduced advanced grain cleaning solution which significantly helps in reducing the mycotoxin levels. Moreover, on 6th March 2018, Marlen International, Inc. introduced new Afoheat, Carruthers, and Unitherm food processing equipment at Anuga FoodTec, Germany. In addition to this, to tap into the emerging market, the key players are focusing on acquisition and merger strategy to maintain its presence all over the world. Thus, the strategic product portfolio will help to gain more share value during the forecast period. 

Based on the equipment type, the market is segmented into mixers, depositors, refrigeration, slicers and dicers, thermal equipment, extruding machines, and others. Among which, thermal is expected to be the fastest growing segment in the market due to its enormous application in the food industry.

*Download Free Report Brochure: *https://www.zionmarketresearch.com/requestbrochure/food-processing-equipment-market

Based on the application, the global food processing equipment market is categorized into the dairy sector, fisheries, meat and poultry, fruits and vegetables, bakery and confectionery. Among which, bakery & confectionary segment held a dominant position in the global market throughout the forecast period. Rising demand for easy-to-cook food products and increasing consumption of bakery & confectionary products across the globe is expected to attain significant market share value within the forecast period. 

Asia Pacific is the fastest growing region in the global food processing market owing to growing demand for convenient and processed food products in emerging economies such as China and India. The growth of the Asia Pacific food processing equipment is at a high pace due to the rising number of food product manufacturers, improving lifestyle along with the rising disposable income, stable economic growth in this region. Besides, Asia Pacific is likely to experience a sharp increase in the demand for the advanced food processing equipment which will help to minimize processing time and improve the efficiency of manufacturing operations. The predicted growth in this region for the number of food processing units is further expected to fuel the supply and utilization of food processing equipment.

*Know More About Discount on This Report: *https://www.zionmarketresearch.com/requestdiscount/food-processing-equipment-market

Followed by Asia Pacific, North America is expected to display significant growth in the global food processing equipment market within the forecast period. Types of equipment vary with the different region; the U.S. food processing equipment holds a major market share as the U.S. is ranked 3rd in the consumption of processed foods. Furthermore, safety and quality standards created by the FDA have facilitated the U.S. in the manufacturing of safe food products and also have increased the reliance on such food products. Therefore, food manufacturing industries are providing healthy and safe food products to their customers which will eventually drive the overall market growth in this region.

In the Europe region, the UK, France, Germany, and Italy, food processing equipment market will show steady growth over the forecast period. Germany held a major market share in this region due to their diverse food & beverage market. Latin America and the Middle East & Africa are poised to be the growth engines for the food processing equipment market during the forecast period.

Browse the full *"Food Processing Equipment Market By Equipment Type (Mixers, Depositors, Refrigeration, Slicers And Dicers, Thermal Equipment, Extruding Machines, And Others) and by Application (Dairy Sector, Fisheries, Meat And Poultry, Fruits And Vegetables, Bakery And Confectionery): Global Industry Perspective, Comprehensive Analysis And Forecast, 2017 – 2024" *report at https://www.zionmarketresearch.com/report/food-processing-equipment-market

The report also includes detailed profiles of key players such as Scherjon, SPX, Maschinenbau Rud Baader, A&B Process Systems, Marlen International, Paul Mueller, Anko Food Machine Company Limited, and Bettcher Industries Incorporated. The detailed description of players includes parameters such as company overview, financial overview, business strategies, and recent developments of the company. 

*Inquire more about this report before purchase @ *https://www.zionmarketresearch.com/inquiry/food-processing-equipment-market

*This report segments the global food processing equipment market as follows:*

*Global Food Processing Equipment Market: Equipment Type Segment Analysis*

· Mixers
· Depositors
· Refrigeration
· Slicers and Dicers
· Thermal Equipment
· Extruding Machines 
· Others 

*Global Food Processing Equipment Market: Application Segment Analysis*

· Dairy Sector
· Fisheries 
· Meat and Poultry
· Fruits and Vegetables
· Bakery and Confectionery 

*Global Food Processing Equipment Market: Regional Segment Analysis*

· North America

· The U.S.

· Europe

· UK
· France
· Germany

· Asia Pacific

· China
· Japan
· India

· Latin America

· Brazil

· The Middle East and Africa

*Related Reports:*

· *Microwavable Foods Market: *https://www.zionmarketresearch.com/report/microwavable-foods-market
· *Cold Chain Market:* https://www.zionmarketresearch.com/report/cold-chain-market
· *Frozen Bakery Products Market:* https://www.zionmarketresearch.com/report/frozen-bakery-products-market
· *Food & Beverage Metal Cans Market:* https://www.zionmarketresearch.com/report/food-beverage-metal-cans-market
· *Nutraceuticals Market:* https://www.zionmarketresearch.com/report/nutraceuticals-market

*About Us:*

Zion Market Research is an obligated company. We create futuristic, cutting-edge, informative reports ranging from industry reports, company reports to country reports. We provide our clients not only with market statistics unveiled by avowed private publishers and public organizations but also with vogue and newest industry reports along with pre-eminent and niche company profiles. Our database of market research reports comprises a wide variety of reports from cardinal industries. Our database is been updated constantly in order to fulfill our clients with prompt and direct online access to our database. Keeping in mind the client’s needs, we have included expert insights on global industries, products, and market trends in this database. Last but not the least, we make it our duty to ensure the success of clients connected to us—after all—if you do well, a little of the light shines on us.

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*Blog:* http://zmrblog.com Reported by GlobeNewswire 2 hours ago.

Xbrane Biopharma announces product portfolio update with a new full strategic focus on biosimilars

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*Press release*
*2018-09-10*

*The board of directors of* *Xbrane Biopharma (publ.) ("Xbrane" or the Company) has decided to shift strategic focus in the Company's product pipeline to biosimilars. As Xbranes leading biosimilar Xlucane (ranibizumab (Lucentis**®**) biosimilar) moves into the pivotal clinical trial, Xbrane is accelerating development of Xcimzane (certoizumab pegol (Cimzia**®**)* *biosimilar) and Xoncane (pegaspargase (Oncaspar®)* *biosimilar) and will initiate development of two additional biosimilars on biologics with patent expiration 2026-2028. As a consequence of the Company's strategic focus of capital and resources on biosimilars, further development of generic long acting injectables beyond Spherotide (generic long acting triptorelin) will only be pursued if additional resources become available.*

*Strategic focus on biosimilars*
The co-development agreement for Xlucane entered with STADA Arzneimittel AG in July 2018 validated the quality and commercial viability of Xbranes technological platform and capability in biosimilar development. This combined with the inherent attractiveness, particularly considering the favourable risk/reward profile, of biosimilars, the board of directors of Xbrane has decided to dedicate the absolute majority of the Company's development resources to biosimilars going forward. As a consequence of this, further development of generic long acting injectables beyond Spherotide will only be further pursued if additional resources become available, either internally or via strategic partnerships. This concerns specifically generic long acting risperidone, leuprolide, exenatide and octreotide.

*Accelerated development of Xcimzane and Xoncane*
Xbrane is accelerating the development of Xcimzane (certoizumab pegol (Cimzia*®*) biosimilar), and Xoncane (pegaspargase (Oncaspar*®*) biosimilar. Cimzia*®* is a TNF inhibitor approved for treatment of rheumatoid arthritis, psoriasis and Crohn's disease with annual sales of €1.4 billion in 2017. The main patents are set to expire in 2024 in Europe and the US. Oncaspar*®* is used in the treatment of acute lymphocytic leukaemia, a disease affecting especially children. The product had annual sales of approx. USD 0.2 billion in 2017. Xbrane is currently, in the development of both Xcimzane and Xoncane, leveraging the Company's patented E.coli based protein expression technology with significant yield and cost advantage compared to standard systems.

"As Xlucane moves into the clinical trial we are now able to dedicate more development resources to Xcimzane and Xoncane programs. We are excited about these programs as we see very limited competition and an opportunity to bring the first biosimilars to market. Further, both products are well suited for our patented protein expression technology that will provide us with a cost advantage." says Martin Åmark, CEO Xbrane.

*Initiating development of two additional biosimilars*
Xbrane is in the process of expanding its technological platform and capabilities to development of mammalian cell-based biosimilars. Xbrane do this by leveraging its unique technology, competence and know-how already established, in combination with strategic partnerships and few key recruitments. Based on this expanded platform Xbrane is initiating development of two additional biosimilars on biologics with patent expirations 2026-2028.

"In our ambition of becoming a world leading biosimilar developer it is critical for us to expand our technological platform into mammalian cell-based products. We do this leveraging our unique technological platform and capabilities already established in combination with select strategic partnerships and recruitments. We see multiple attractive opportunities to address and we have decided to develop two biosimilars on two fast growing biologics with a current combined global sale well above USD 5 billion with patent expiration 2026-2028. Now is the right time to initiate development of biosimilars to these biologics and we see the opportunity to be ahead of the game and to be amongst the first to launch." says Anders Tullgren, Chairman of the Board of Xbrane.

Initially the development of the biosimilars in the pipeline is done with freed up resources from Xlucane development, however long-term successful development requires that sufficient capital can be raised in the market.

*For further information, please contact:*
Martin Åmark
Chief Executive Officer
M: +46 (0) 763-093 777
E: martin.amark@xbrane.com

Susanna Helgesen
CFO/IR, Xbrane Biopharma AB
M: +46 (0) 708-278 636
E: susanna.helgesen@xbrane.com

*About Xbrane *
Xbrane is a commercial phase Swedish biopharmaceutical company specialized in biosimilars. Xbrane has a patented protein production platform for development of biosimilars and world leading expertise in biosimilars. Xbrane's headquarter is located in Solna outside of Stockholm and the company's in-house research and development facilities are in Sweden and Italy. Xbrane is listed at Nasdaq First North since February 3rd, 2016 under the name XBRANE and Avanza Bank AB is Xbrane's certified adviser. For more information see www.xbrane.com.

This information is information that Xbrane Biopharma AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 10 September at 08.00 2018.

*Attachment*

· Xbrane announces product portfolio update.pdf Reported by GlobeNewswire 2 hours ago.

News24.com | WATCH: Spanish police raid turtle farm

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Spanish police have shut down what they believe to be Europe's biggest illegal turtle farm, selling endangered species. Reported by News24 2 hours ago.

AIR Worldwide Releases Severe Thunderstorm Model for Europe

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For Immediate Release:

*AIR Worldwide Releases Severe Thunderstorm Model for Europe *

BOSTON, Sept. 10, 2018 - Catastrophe risk modeling firm AIR Worldwide today announced that it has released a new state-of-the-art severe thunderstorm model for Europe. The AIR Severe Thunderstorm Model for Europe captures the effects of straight-line winds and hail, enabling companies to assess their risk from the local scale to the macro level on insured properties, including residential, commercial, automobiles, and specialty lines of business-in 22 countries. Together with AIR's Extratropical Cyclone Model for Europe and European flood models, this new model now allows for a comprehensive assessment of atmospheric risk in this region. AIR Worldwide is a Verisk (Nasdaq:VRSK) business.

"Though typically associated with the summer months, severe thunderstorms can strike Europe at any time of the year, and their loss potential is increasing," said Dr. Eric Robinson, manager and principal scientist, AIR Worldwide. "A severe thunderstorm event can, over the course of several days, produce multiple outbreaks. Depending upon the region, high-frequency severe thunderstorms can contribute up to 50 percent to overall wind-related insured losses in Europe."

The scientifically advanced severe thunderstorm model realistically simulates the highly localized effects of individual hail and straight-line winds (microevents)-from a meteorological perspective the key drivers of loss from severe thunderstorms-and the spatial extent of macroevents (combinations of microevents). This is achieved by replicating daily activity based on a comprehensive analysis of historical storm outbreaks. The model reflects emerging scientific and engineering research and leverages data from many sources, including storm report databases, numerical weather prediction, and an unprecedented amount of radar data from recent events. To validate the model, AIR used a large set of claims data, including detailed claims from some of the largest insurers in Europe.

"Because of the localized nature of individual hailstorms and straight-line winds as well as potential for major outbreaks affecting the ever-changing built environment, using historical losses for risk assessment and management is not sufficient," said Dr. Cagdas Kafali, senior vice president, research and modeling, AIR Worldwide. "The model was built to meet the wide spectrum of severe thunderstorm risk management needs of all stakeholders, including the insurance and reinsurance industry, and accounts for insurance policy conditions specific to each modeled country."

In addition, AIR announced that it updated its Extratropical Cyclone Model for Europe, including the expansion of the model domain covering a total of 22 countries. The updated model includes support for several new risk types, including large industrial facilities, wind turbines, marine cargo, and builder's risk. The AIR Extratropical Cyclone Model for Europe also features a new stochastic event set, updated hazard and vulnerability modules, and industry exposure databases.

Dr. Kafali concluded, "Used in concert, the AIR Extratropical Cyclone Model for Europe, the AIR Inland Flood Model for Europe, and the new severe thunderstorm model provide a comprehensive view of atmospheric peril risk for effective risk management. Together, they can help insurers identify opportunities for growth and make more informed underwriting decisions. Reinsurers also benefit from this toolkit, which enables them to better understand and effectively price the risk that they may be assuming on their books."

The AIR Severe Thunderstorm Model for Europe and the AIR Extratropical Cyclone Model for Europe are currently available in the Touchstone^® and CATRADER^® catastrophe risk management systems.

*About AIR Worldwide*
AIR Worldwide (AIR) provides risk modeling solutions that make individuals, businesses, and society more resilient to extreme events. In 1987, AIR Worldwide founded the catastrophe modeling industry and today models the risk from natural catastrophes, terrorism, pandemics, casualty catastrophes, and cyber incidents. Insurance, reinsurance, financial, corporate, and government clients rely on AIR's advanced science, software, and consulting services for catastrophe risk management, insurance-linked securities, longevity modeling, site-specific engineering analyses, and agricultural risk management. AIR Worldwide, a Verisk (Nasdaq:VRSK) business, is headquartered in Boston, with additional offices in North America, Europe, and Asia. For more information, please visit www.air-worldwide.com.

###

For more information, contact:
Kevin Long
AIR Worldwide
+1-617-267-6645
klong@air-worldwide.com Reported by GlobeNewswire 2 hours ago.

Carmila is continuing with the transformation of its Cité Europe regional shopping centre (Calais, northern France) and strengthening its commercial attractiveness with Primark

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Carmila is continuing with the transformation of its Cité Europe regional shopping centre (Calais, northern France) and strengthening its commercial attractiveness with Primark BOULOGNE-BILLANCOURT, France--(BUSINESS WIRE)--Regulatory News: Carmila (Paris:CARM) has just signed its first lease in France with Primark for a location in Cité Europe, the Coquelles regional shopping centre in the Calais urban area (northern France). This signing marks a major milestone in the relaunch of this well-established leading commercial centre, which began with its acquisition back in 2014. The fashion retailer will occupy a sales area of more than 4,000 m² of retail selling space s Reported by Business Wire 2 hours ago.

Beeswax Appoints Cadi Jones As Commercial Director in EMEA

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US-based programmatic buying platform makes strategic hire of seasoned adtech executive to facilitate continued growth globally

NEW YORK, Sept. 10, 2018 (GLOBE NEWSWIRE) -- Beeswax, the industry’s first extensible programmatic buying platform, has appointed Cadi Jones as Commercial Director in its London office to support expanded demand for its services across Europe.As former Commercial Innovation Director at Clear Channel International, an out-of-home advertising company, Jones was tasked with leading that company’s global programmatic advertising strategy and the development of its digital strategy.  Ms. Jones helped create a unique out-of-home programmatic offering, pivoting a traditional media company into the modern era of targeted, automated digital advertising.

At Beeswax, Ms. Jones will lead a growing commercial team as it continues to land and service major deals with enterprise brands requiring sophisticated programmatic solutions. Her extensive experience in programmatic will be instrumental to the partnerships that Beeswax has developed in Europe and she will be tasked with expanding its international presence.

“Beeswax is one of the most forward-thinking adtech companies in the space,” says Ms. Jones. “It has thought about the needs of the industry before they were ever apparent and offers one of the most comprehensive programmatic platforms on the market.” Jones continues, “I was initially attracted to Beeswax because of the flexibility of the product and look forward to being part of its growth.”

Beeswax’s Bidder-as-a-Service™ provides advertisers and media companies unprecedented control and customization over their programmatic media buying. The platform unlocks access to tailored supply, custom optimization, and granular visibility into data and reporting, providing each customer with a bespoke solution based on the unique needs of their business. This approach has led more than 50 forward-thinking brands and media companies to license the BaaS solution, including Overstock, Legendary Entertainment’s Applied Analytics division, Foursquare and TreSensa.

“Our expansion into the European market began more than a year ago and has steadily grown as the market demands more control over media spend,” said Ari Paparo, CEO and Founder of Beeswax. “The hire of Cadi Jones marks a significant moment for Beeswax and its investment in providing global brands the technology that they need to be successful in programmatic.”

*About Beeswax*
Founded by a team of former Google and DoubleClick advertising leaders, Beeswax is pioneering the industry's first Bidder-as-a-Service™ (“BaaS”). Programmatic digital advertising remains an exciting and innovative arena, and the smartest buyers require technically-sophisticated, highly customizable solutions. We believe that using an RTB bidder should be as easy as using any part of the marketing cloud.

*Media Contact*
WIT Strategy, for Beeswax
Rich Cherecwich
rcherecwich@witstrategy.com Reported by GlobeNewswire 39 minutes ago.

Hannover Re anticipates stable prices and conditions for 2019 following last year's large loss events

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DGAP-News: Hannover Rück SE / Key word(s): Miscellaneous

10.09.2018 / 09:00
The issuer is solely responsible for the content of this announcement.
--------------------

*Press Release*

*Hannover Re anticipates stable prices and conditions **for 2019 following last year's large loss events*

Monte Carlo, 10 September 2018: The market environment in worldwide property and casualty reinsurance remains challenging. The enormous natural catastrophe losses of the past year led to an increase of reinsurance rates in affected regions and programmes, which however were lower than expected. At loss-free programmes, rates tend to stabilize.

Competition continues to be intense and is clearly shaping the pricing situation. At the same time, the capital resources available to most insurers can be described as good, as is also reflected in retention levels. These are still high, suppressing demand for reinsurance coverage. The ILS (insurance-linked securities) market also continues to provide considerable capacities, adding to the pressure on prices and conditions.

A gradual shift in sentiment can nevertheless be discerned in the industry. The results posted by some companies deteriorated sharply in 2017. Some reinsurers' results in 2018 were also impacted by follow-up losses from natural disasters. Furthermore, diminished run-off profits must be expected. Rising inflation - fuelled in part by new trade barriers - is pressuring the industry to increasingly implement rate adjustments in some segments.

Merely moderate rate increases overall have so far emerged out of the price negotiations within the year. In the case of natural catastrophe business, which had been hard hit in the previous year, more appreciable mark-ups were nevertheless recorded for loss-impacted treaties. All in all, the rate quality in the reinsurance market is slightly improved year-on-year, albeit remaining on a low while still adequate level.

"The further development of the loss amounts from last year's hurricanes as well as the minimal large losses incurred in the current year to date will be crucial in determining prices in property and casualty reinsurance", CEO Ulrich Wallin commented during a press conference in Monte Carlo. "The lower the strains from catastrophe losses turn out to be this year, the more difficult it will be to push through requisite additional price increases in the coming year. Nevertheless, we are seeing strong demand and hence rather favourable opportunities for growth in certain segments."

Hannover Re anticipates increasing demand in, among other areas, covers for cyber risks as well as solutions designed to provide solvency relief under structured reinsurance.

For the treaty renewals as at 1 January 2019 the Group therefore expects - despite the overabundance of reinsurance capacity - stable prices and conditions for the most part. Similarly, an industry-wide softening in profitability as well as a higher burden of attritional losses point to a need for improved market conditions.

For the three pillars of its property and casualty reinsurance - namely target markets, specialty lines and global reinsurance - Hannover Re anticipates the following developments in the treaty renewals as at 1 January 2019:*I. Target markets:*

*North America*
The economy and the North American primary insurance market continue to develop favourably. The rate level remains stable overall and further steady growth can therefore be anticipated. Markets are still fiercely competitive, with both property and casualty business seeing vigorous competition despite the ongoing trend of mid-sized losses.

The hurricanes and Californian wildfires of the previous year caused very significant losses on both the insurance and reinsurance side. Capacity in the market nevertheless remains unaffected, as a consequence of which the price adjustments even under loss-impacted programmes were moderate. While appreciable increases were recorded, the similarly anticipated impact on loss-free programmes failed to materialise.

The market is currently preoccupied with the issue of sustainable coverage concepts for flood and terrorism risks.

In the case of proportional reinsurance covers Hannover Re expects to see - especially in property insurance - a slight reduction in commissions and stable treaty conditions, which will continue to be driven by losses from forest fires and windstorm events. Non-proportional reinsurance is in a robust state that promises risk-appropriate treaty conditions for the upcoming renewals as well, with further modest price adjustments anticipated in property insurance overall. Interest in covers offering solvency relief is picking up again, with the result that here too Hannover Re expects to see stronger demand.

*Continental Europe*
The markets of Northern, Eastern and Central Europe are grouped together under Continental Europe. The largest single market is Germany.

Germany: Hannover Re expects to see continued growth on the German property and casualty primary insurance market. It is open to question, however, whether the previous year's level can be matched, in part because of the increasing competition emerging on the motor insurance market. Homeowners' comprehensive insurance is still in need of remedial action. As things currently stand, the strains caused by events such as winter storm Friederike in January of this year and various heavy rainfall events are likely to have reinsurance implications only in isolated instances because in many cases they remained within the retention run by primary insurers.

In motor insurance the earnings situation is clouded by the onset of more lively competition. For 2019 Hannover Re currently anticipates growth of just under two percent for the total market in terms of policy numbers, with at most a break-even result. Average claim amounts in motor third party liability insurance are continuing to rise. Claims frequency continues to decline, though less pronounced than in the previous years. Against this backdrop Hannover Re sees a need for adjustments with respect to some customer accounts depending on the performance of motor reinsurance cessions. The influence of telematics tariffs and developments relating to self-driving vehicles on the market as a whole continues to be assessed as relatively slight.

Growth opportunities can be discerned in the area of cyber insurance. It is Hannover Re's expectation that insurers will focus more closely on commercial customers and small and mid-sized enterprises in this segment over the coming year.

Central and Eastern Europe: In primary insurance the market in Europe continues to be shaped by surplus capacities. Reinsurance markets consequently also remain fiercely competitive, even though prices are more stable than in the previous year. Most notably, covers for risks in the fire, industrial and motor insurance lines are seeing sustained intense competition.

In France the rivalry among primary insurers in motor business remains focused primarily on the pricing side, while at the same time the claims incidence is high. Industrial risks are seeing continued price erosion. Many insurers are therefore concentrating on SMEs, thereby increasing the pressure on prices in this area too. As a further factor, rising inflation rates are adding to the cost of settling claims, as is also true of other markets. Thanks to the improved state of the economy, modest growth can nevertheless be observed in primary insurance business. The upturn in construction activity noted in the previous year has been sustained, which Hannover Re should continue to benefit from in view of its leading position in builder's risk insurance.

Competition on the reinsurance side remains fierce, just as it is on the primary market, not least given the absence of extraordinary losses in the first half of the year. The frequency of more minor natural catastrophe events was, however, on an unchanged high level.

Growth rates in the countries of Eastern Europe, on the whole, continue to be higher than the overall European average. This is true of both the primary and reinsurance market. New rules governing compensation for relatives will lead to further premium hikes in motor insurance. The brisk demand for top-quality reinsurance solutions remains undiminished across the entire region. Key drivers here include tighter requirements placed on insurers' capital resources by Solvency II as well as more rigorous regulatory oversight and anticipated changes in accounting principles. Despite intense competition, sizeable growth opportunities can be expected in Eastern Europe over the medium to long term - against a backdrop of continuing broadly adequate reinsurance prices and conditions.

In view of its robust position in the market, it is Hannover Re's assumption that the company will be able to further expand its customer relationships. Demand for high-grade reinsurance solutions remains strong.*II. Specialty lines:*

*Aviation*
The stabilising tendencies that could already be discerned on the primary market for aviation insurance last year have been sustained. In certain segments, such as the market for small planes and corporate jets, it was possible to secure rate increases in some cases. At the same time, the capacity available on the primary market was lower than in the previous year due to the discontinuation of business activities by some players, especially on the London Market.

On the reinsurance side capacity remains unchanged, although here too a trend towards stabilisation can be detected thanks to the disciplined underwriting approach adopted by some market participants. Very much as in the original market, therefore, Hannover Re anticipates a longer-term and piecemeal improvement in the market environment.

Particularly when it comes to globally operating airlines, initial indications can be observed on the primary insurance market of a stabilisation in prices. Over the short to medium term, however, Hannover Re does not expect to see any significant change in the overall situation owing to the continued abundant supply of insurance and reinsurance capacity. The pricing level in the space segment remains under pressure due to an excess of capacity and the consistent success of proven space launch systems.

*Marine*
The losses incurred from natural catastrophe events in the second half of 2017 brought about some stabilisation in marine business. Moderate and in some instances appreciable price increases were obtained on the particularly hard-hit London Market in the renewals during the first half of 2018. It remains to be seen, however, whether this trend will be sustained in 2019. While overall results for the marine insurance segment continue to be inadequate on the primary side, the very low loss experience to date in 2018 may further ease the pressure for additional price increases in the short term.

In the offshore energy sector the upswing in the price of oil in 2017 and 2018 prompted a slow resurgence in demand for primary insurance covers. Nevertheless, the premium volume for this sub-segment of marine insurance is still well below the highs of 2014. Unlike in 2015 and 2016, large losses were absent in 2017 and also thus far in the first half of 2018, hence enabling primary insurers and reinsurers to report at least good results. Hannover Re only expects to see a sustained improvement in the premium and rate trend in this segment over the medium term.

*Credit and surety *
Compared to prior years, the loss ratios in credit and surety insurance as well as political risks business are slightly higher. The loss experience is characterised by a stable claims frequency on a good level and modestly rising loss amounts in individual cases. The elevated claim costs witnessed in emerging markets in previous years have now retreated again, although they are still on the high side viewed from a multi-year perspective. With this in mind, prices for insurance and reinsurance should remain stable; demand for reinsurance covers in the area of credit, surety and political risks is either stable or trending slightly higher.

*United Kingdom / Ireland*
The climate on the primary insurance market in the United Kingdom and Ireland continues to be intensely competitive. Thanks also in part to the initiative launched by Lloyd's to take a critical look at the business results reported by syndicates, Hannover Re expects at least a stable environment in this market.

In property reinsurance, too, Hannover Re was able to secure double-digit price increases on business impacted by hurricanes Harvey, Irma and Maria. Stable rates and conditions were negotiated in all other lines of reinsurance.

Further price increases on liability reinsurance business covering private customer portfolios - and hence affected by the 2017 cut in the Ogden rate - are unlikely in 2019. The rate improvements obtained in the various rounds of renewals since the spring of 2017 were well into the double-digit percentage range.

 

*III. Global reinsurance:*

*Catastrophe business *
Even after what can certainly be described as the historic hurricane losses of the past year, there has been no change in the prevailing oversupply of reinsurance capacity shaping worldwide natural catastrophe business. As a further factor, the considerable capacities originating from the ILS market remain undiminished. Overall, this led to a merely modest increase in prices for property catastrophe business that was driven by loss-impacted programmes, although here too the rate increases came in below market expectations.

Hannover Re anticipates the following developments on individual markets for natural catastrophe risks:

North America: The recent mid-year treaty renewals brought modest rate rises. In Florida increases of around 20 percent were generated under loss-affected programmes, with improvements otherwise in the low single digits. If there are no appreciable losses in the current year, it will likely be difficult to push through further rate increases for the coming year. Growing demand for reinsurance coverage can be observed from state-backed programmes offering protection against flood risks. Subject to commensurate prices, Hannover Re would be prepared to make capacity available for such covers.

Europe: European reinsurance markets have seen less change in the sustained pressure on prices. The protracted soft market is most striking in United Kingdom but is also evident for Germany, where there are currently no grounds to anticipate a shift in market conditions. The losses caused by the forest fires in Sweden are unlikely to be reflected on the pricing side.

Japan: Modest price reductions for catastrophe covers were observed here in the current year. The flood losses in Hiroshima prefecture will probably have no appreciable effect on demand for reinsurance capacity or prices. In the next round of treaty renewals for Japan on 1 April 2019 the price level is therefore expected to remain roughly stable.

Australia / New Zealand: The earthquake losses in New Zealand from 2016 have stabilised rates there; negative run-offs are still being seen, however, prompting some providers to take a rather cautious approach. In Australia, on the other hand, prices remain under pressure - although the pain threshold for further price reductions has now been reached. Reinsurers with a very good rating, long-standing expertise and excellent business relationships - such as Hannover Re - have opportunities to secure more attractive prices than the market as a whole, especially in Australia.

Latin America: The markets of Central and South America continue to post above-growth rates, albeit with substantial differences from country to country. Most markets are still seeing elevated demand for high-quality reinsurance protection, enabling financially robust reinsurers to book business at adequate prices. Recent acquisitions of sizeable portfolios by primary insurers in Latin America have generated a greater need for reinsurance capacity, a development from which Hannover Re is also benefiting.

Caribbean: Caribbean nations were hit hard by the hurricane losses of the past year. The renewals as at 1 July consequently saw price increases of up to 40 percent under loss-affected programmes, while the figure was around 10 percent for programmes that had escaped unscathed. Hannover Re is a well-established market player in this region. Further price increases after the sharp rises seen in the current year are, however, rather unlikely if no additional losses are incurred.

*Worldwide treaty business*
Developments in worldwide treaty business varied across markets and regions.

Asia-Pacific: In what is a very mixed region from a reinsurance standpoint, Hannover Re continues to trust in its strategy of diversification - both in terms of the coverage offered and its regional positioning. Through special extensions of the book of business written with selected target customers Hannover Re is able to secure profitability and growth for the medium term. This is backed by further strengthening of the local network.

Latin America: Larger ceding companies, in particular, prefer to work with only a limited number of reinsurers, primarily the major providers. One reason here is the significant natural disasters of 2017, which showed which reinsurers were in a position to promptly meet their payment obligations. Consequently, Hannover Re benefited considerably from an increased demand for natural catastrophe coverage in Latin America.

Agricultural risks: The growing need for agricultural commodities and foodstuffs as well as the increased prevalence of extreme weather events continue to stimulate demand for insurance and reinsurance solutions, especially in emerging and developing countries. The "InsuResilience" initiative launched by the G7 countries has, for example, set itself the goal of improving access to insurance coverage against climate risks for millions of particularly poor and vulnerable people in developing countries by 2020.

The increasingly widespread implementation of public-private partnerships is opening up new opportunities for Hannover Re to write profitable business in markets that have still to establish themselves. Furthermore, the growing availability of new technologies, including for example remote sensing by satellites, is enabling continuing expansion of this segment with innovative and efficient insurance products such as parametric covers.

In Germany the dry and arid conditions of the summer of 2018 have not as yet become an issue for the insurance industry because agricultural covers here are focused virtually exclusively on hail risks.

Insurance-Linked Securities: Hannover Re accesses the ILS market both to obtain protection for its own catastrophe risks and to transfer its clients' life & health and property & casualty risks to the capital market. The latter primarily takes the form of collateralised reinsurance, which is still the largest business segment within Hannover Re's ILS activities, but is also supplemented by the issuance of catastrophe bonds. In 2018, for example, the company has so far brought four catastrophe bonds to market for US clients with a total volume of around USD 1.4 billion. Over the coming years Hannover Re expects demand to show moderate growth overall. The company is also itself an investor in catastrophe bonds, thereby maximising all the opportunities offered by the ILS market.

Structured reinsurance/Advanced Solutions: This business delivered strong growth in the current year across all regions, especially in North and South America as well as in Europe. Not only did the average premium per contract increase, but also the number of contracts in absolute terms. Going forward, Hannover Re expects a further rise in demand for innovative and tailor-made reinsurance solutions.

Growth opportunities on a continuing high level are anticipated in North America, Europe and Asia. The purchasing habits of many clients have changed of late, reflecting a shift towards holistic reinsurance solutions. This trend shows no sign of abating and will mean that in the future, too, more and more customers will be calling for increasingly complex reinsurance solutions. It is still too early to foresee what effect the adoption of IFRS 17 will have on structured reinsurance business. Nevertheless, implementation should generate stronger demand for reinsurance solutions, driven by the further increase in the complexity of capital and risk management faced by customers.

*Outlook *

Hannover Re expects to see stability in prices and conditions overall for the treaty renewals as at 1 January 2019. While improvements should be possible under loss-impacted programmes, covers that were spared any losses have reached the minimum level from a technical standpoint. Ultimately, though, when it comes to determining prices it still remains to be seen how the major loss situation for 2018 ends up, how large losses from the previous year continue to develop, how inflation turns out and whether the run-off results from reserves in the US casualty market deteriorate.

As has been apparent from the renewals over the course of the year, broadly diversified reinsurers with expertise and a very good rating are able to profit from the current state of the market. Hannover Re has thus been highly satisfied with the business renewed to date in 2018. Looking ahead to 2019, further promising possibilities should open up. Along with the opportunities arising out of digitalisation, demand for coverage of cyber risks - not just from large corporations but now also from SMEs - is on the rise. Similarly, business in the Asian growth markets (China, India) should also present some openings. Structured reinsurance offers further scope for growth in covers taken out for capital relief as a consequence of the implementation of risk-based solvency systems.

In the present climate Hannover Re will stay focused on its core competence: traditional reinsurance, supplemented by individual coverage concepts such as product-oriented cooperation arrangements with primary insurance customers. As in the previous year, the company is concentrating on consistently growing its existing high-quality book of business, complemented by strategic partnerships. In addition, Hannover Re will take advantage of opportunities that arise in niche and specialty segments. As was true of earlier soft market phases, the guiding principle is to only write business that satisfies margin requirements; at the same time, though, it remains important to offer customers alternative solutions at an appropriate price level.

"The positive future prospects for the global reinsurance market are the cornerstone of our success over the medium and long term. With this in mind, we are concentrating quite deliberately on the products and services typically associated with a reinsurer", Mr. Wallin asserted. "We have no doubt that this is the right course to pursue when it comes to generating sustainable value for our clients, our shareholders and our employees."

In view of the business development so far in the current financial year and the company's very good positioning in the market, Hannover Re considers itself well on track to achieve its 2018 year-end targets. Based on constant exchange rates, the company anticipates an increase of more than 10% in its gross premium volume and net income in excess of EUR 1 billion for its total business. This is conditional upon major loss expenditure not significantly exceeding the budgeted level of EUR 825 million and assumes that there are no unforeseen distortions on capital markets.

*Hannover Re, *with gross premium of EUR 17.8 billion, is the fourth-largest reinsurer in the world. It transacts all lines of property & casualty and life & health reinsurance and is present on all continents with around 3,300 staff. Established in 1966, the Hannover Re Group today has a network of more than 140 subsidiaries, branches and representative offices worldwide. The Group's German business is written by the subsidiary E+S Rück. The rating agencies most relevant to the insurance industry have awarded both Hannover Re and E+S Rück outstanding financial strength ratings: Standard & Poor's AA- "Very Strong" and A.M. Best A+ "Superior".

Please note the disclaimer:
https://www.hannover-re.com/535917*Contact*
 
*Corporate Communications:*
Karl Steinle
tel. +49 511 5604-1500
karl.steinle@hannover-re.com
 
*Media Relations: *
Oliver Suess
tel. +49 511 5604-1502
oliver.suess@hannover-re.com
 
Saskia Ahrens
tel. +49 511 5604-6322
saskia.ahrens@hannover-re.com
 
*Investor Relations: *
Julia Hartmann
tel. +49 511 5604-1529
julia.hartmann@hannover-re.com
 
www.hannover-re.com
 
 
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10.09.2018 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de --------------------

Language: English
Company: Hannover Rück SE
Karl-Wiechert-Allee 50
30625 Hannover
Germany
Phone: +49-(0)511-5604-1500
Fax: +49-(0)511-5604-1648
Internet: www.hannover-re.com
ISIN: DE0008402215
WKN: 840 221
Indices: MDAX
Listed: Regulated Market in Frankfurt (Prime Standard), Hanover; Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange; Luxembourg Stock Exchange
 
End of News DGAP News Service Reported by EQS Group 1 hour ago.

Valencia latest Spanish club to fleece fans for Champions League payday and Uefa need to stop overcharging away supporters

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From one angle US$98 doesn’t seem too bad a price to see Valencia take on Manchester United in a Uefa Champions League game in December. The price is similar to a big concert, theatre production or NFL game, though a standing ticket to see the New York Giants at the Dallas Cowboys cost US$40 this Sunday. Valencia vs United could be a crucial game in one of Europe’s most thrilling venues to decide which team goes through. Or it could be a dead rubber. But both clubs are big names and... Reported by S.China Morning Post 1 hour ago.

STATS’ Limerick Director to Present at SportsTech Ireland Innovation Masterclass

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STATS’ Limerick Director to Present at SportsTech Ireland Innovation Masterclass LIMERICK, Ireland--(BUSINESS WIRE)--Today, STATS, the worldwide leader in sports data and intelligence, announced that Gráinne Barry, Regional Operations Director of Europe, Middle East and Africa (EMEA), will present as a member of a data analytics panel at the 2018 SportsTech Ireland Masterclass in Sports Entrepreneurship on Friday, 21 Sept. The two-day Masterclass (21-22 Sept.) will look at the global picture and emerging trends in entrepreneurship within sports business, featuring executive Reported by Business Wire 59 minutes ago.

In 1st key speech, new UN rights chief airs concerns

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GENEVA (AP) — The new U.N. human rights chief is warning of abuses worldwide, citing among others the Trump administration's "unconscionable" separations of migrant families and urging Europe to create a dedicated search and rescue... Reported by New Zealand Herald 17 minutes ago.

A decade after Lehman, Europe still on economic crutch

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Ten years after the collapse of Lehman Brothers and the onset of the global financial crisis, much of the industrialised world has yet to fully recover. Reported by RTE.ie 18 minutes ago.

Net Asset Value(s)

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*WisdomTree Issuer plc – Daily Fund Prices * *07-September-18*
* * * *

               

WisdomTree AT1 CoCo Bond UCITS ETF  – USD 07/09/2018 IE00BZ0XVF52 308045 USD 29,643,308.06 96.2304
WisdomTree AT1 CoCo Bond UCITS ETF – EUR Hedged 07/09/2018 IE00BFNNN236 20828 EUR 2,084,707.95 100.0916
WisdomTree AT1 CoCo Bond UCITS ETF – GBP Hedged 07/09/2018 IE00BFNNN459 20740 GBP 2,077,240.85 100.1563
WisdomTree AT1 CoCo Bond UCITS ETF – USD Acc 07/09/2018 IE00BZ0XVG69 9000 USD 869,933.29 96.6593
WisdomTree AT1 CoCo Bond UCITS ETF – USD Hedged 07/09/2018 IE00BFNNN012 20962 USD 2,101,018.69 100.2299
WisdomTree CBOE S&P 500 PutWrite UCITS ETF - USD Acc 07/09/2018 IE00BD49R243 1265000 USD 65,793,055.17 52.0103
WisdomTree Emerging Asia Equity Income UCITS ETF 07/09/2018 IE00BYPGT035 1125000 USD 12,547,980.42 11.1538
WisdomTree Emerging Markets Equity Income UCITS ETF 07/09/2018 IE00BQQ3Q067 2042097 USD 30,788,502.67 15.0769
WisdomTree Emerging Markets Equity Income UCITS ETF Acc 07/09/2018 IE00BDF12W49 108242 USD 2,062,641.71 19.0558
WisdomTree Emerging Markets Small Cap Dividend UCITS ETF 07/09/2018 IE00BQZJBM26 1125000 USD 18,971,297.15 16.8634
WisdomTree Enhanced Commodity UCITS ETF – EUR Hedged Acc 07/09/2018 IE00BG88WG77 25000 EUR 246,716.10 9.8686
WisdomTree Enhanced Commodity UCITS ETF – GBP Hedged Acc 07/09/2018 IE00BG88WH84 100000 GBP 987,729.16 9.8773
WisdomTree Enhanced Commodity UCITS ETF - USD 07/09/2018 IE00BZ1GHD37 500000 USD 5,184,156.72 10.3683
WisdomTree Enhanced Commodity UCITS ETF - USD Acc 07/09/2018 IE00BYMLZY74 10250000 USD 106,744,099.09 10.4141
WisdomTree EUR Aggregate Bond Enhanced Yield UCITS ETF – EUR 07/09/2018 IE00BD49R912 30000 EUR 1,494,098.17 49.8033
WisdomTree EUR Aggregate Bond Enhanced Yield UCITS ETF – EUR Acc 07/09/2018 IE00BD49RB39 30000 EUR 1,494,097.91 49.8033
WisdomTree EUR Government Bond Enhanced Yield UCITS ETF 07/09/2018 IE00BD49RJ15 30000 EUR 1,487,649.10 49.5883
WisdomTree EUR Government Bond Enhanced Yield UCITS ETF – EUR Acc 07/09/2018 IE00BD49RK20 30000 EUR 1,487,649.35 49.5883
WisdomTree Europe Equity Income UCITS ETF 07/09/2018 IE00BQZJBX31 3560000 EUR 44,925,285.86 12.6195
WisdomTree Europe Equity Income UCITS ETF Acc 07/09/2018 IE00BDF16007 30010 EUR 432,451.73 14.4103
WisdomTree Europe Equity UCITS ETF - CHF Hedged Acc 07/09/2018 IE00BYQCZT11 17096 CHF 278,389.78 16.2839
WisdomTree Europe Equity UCITS ETF - EUR Acc 07/09/2018 IE00BYQCZX56 1234306 EUR 20,375,998.27 16.5081
WisdomTree Europe Equity UCITS ETF - GBP Hedged 07/09/2018 IE00BYQCZQ89 372454 GBP 4,026,493.74 10.8107
WisdomTree Europe Equity UCITS ETF - USD Hedged 07/09/2018 IE00BVXBH163 3215375 USD 54,815,560.04 17.048
WisdomTree Europe Equity UCITS ETF - USD Hedged Acc 07/09/2018 IE00BYQCZP72 3343137 USD 64,240,984.74 19.2158
WisdomTree Europe Small Cap Dividend UCITS ETF 07/09/2018 IE00BQZJC527 3694859 EUR 62,601,018.33 16.9427
WisdomTree Europe Small Cap Dividend UCITS ETF Acc 07/09/2018 IE00BDF16114 754202 EUR 11,086,796.35 14.7
WisdomTree Eurozone Quality Dividend Growth UCITS ETF - EUR 07/09/2018 IE00BZ56SY76 405833 EUR 6,127,825.03 15.0994
WisdomTree Eurozone Quality Dividend Growth UCITS ETF - EUR Acc 07/09/2018 IE00BZ56TQ67 948013 EUR 15,814,289.66 16.6815
WisdomTree Germany Equity UCITS ETF - CHF Hedged Acc 07/09/2018 IE00BYQCZ914 45884 CHF 819,523.80 17.8608
WisdomTree Germany Equity UCITS ETF - EUR Acc 07/09/2018 IE00BYQCZC44 251123 EUR 3,986,559.43 15.8749
WisdomTree Germany Equity UCITS ETF - GBP Hedged 07/09/2018 IE00BVXBGY20 507894 GBP 5,039,720.77 9.9228
WisdomTree Germany Equity UCITS ETF - USD Hedged 07/09/2018 IE00BYQCZ682 17536 USD 308,452.46 17.5897
WisdomTree Global Quality Dividend Growth UCITS ETF - USD 07/09/2018 IE00BZ56RN96 36780 USD 775,262.86 21.0784
WisdomTree Global Quality Dividend Growth UCITS ETF - USD Acc 07/09/2018 IE00BZ56SW52 355680 USD 7,783,324.52 21.8829
WisdomTree India Quality UCITS ETF - USD 07/09/2018 IE00BDGSNK96 152500 USD 2,803,153.82 18.3813
WisdomTree India Quality UCITS ETF - USD Acc 07/09/2018 IE00BDGSNL04 222500 USD 4,098,901.77 18.422
WisdomTree ISEQ 20 UCITS ETF 07/09/2018 IE00BVFB1H83 1300000 EUR 17,594,593.78 13.5343
WisdomTree Japan Equity UCITS ETF - CHF Hedged Acc 07/09/2018 IE00BYQCZL35 218945 CHF 4,048,836.94 18.4925
WisdomTree Japan Equity UCITS ETF - EUR Hedged Acc 07/09/2018 IE00BYQCZJ13 664839 EUR 10,562,347.51 15.8871
WisdomTree Japan Equity UCITS ETF - GBP Hedged 07/09/2018 IE00BYQCZF74 146865 GBP 1,560,634.41 10.6263
WisdomTree Japan Equity UCITS ETF - JPY Acc 07/09/2018 IE00BYQCZN58 2333721 USD 44,724,659.32 19.1645
WisdomTree Japan Equity UCITS ETF - USD Hedged 07/09/2018 IE00BVXC4854 10231456 USD 163,484,676.64 15.9786
WisdomTree Japan Equity UCITS ETF - USD Hedged Acc 07/09/2018 IE00BYQCZD50 752432 USD 13,092,353.49 17.4
WisdomTree Japan SmallCap Dividend UCITS ETF - USD 07/09/2018 IE00BFXYK923 20000 USD 975,972.66 48.7986
WisdomTree Japan SmallCap Dividend UCITS ETF - USD Acc 07/09/2018 IE00BFXYKD63 20000 USD 975,972.70 48.7986
WisdomTree UK Equity Income UCITS ETF 07/09/2018 IE00BYPGTJ26 840000 GBP 4,488,921.09 5.344
WisdomTree US Equity Income UCITS ETF 07/09/2018 IE00BQZJBQ63 1501445 USD 29,456,692.55 19.6189
WisdomTree US Equity Income UCITS ETF - EUR Hedged Acc 07/09/2018 IE00BD6RZW23 24773 EUR 414,706.14 16.7402
WisdomTree US Equity Income UCITS ETF - GBP Hedged Acc 07/09/2018 IE00BD6RZZ53 155031 GBP 2,326,283.27 15.0053
WisdomTree US Equity Income UCITS ETF Acc 07/09/2018 IE00BD6RZT93 27745 USD 532,130.35 19.1793
WisdomTree US Multifactor UCITS ETF – USD 07/09/2018 IE00BD8ZCY59 10000 USD 519,811.54 51.9812
WisdomTree US Multifactor UCITS ETF – USD Acc 07/09/2018 IE00BD8ZD313 10000 USD 519,811.48 51.9811
WisdomTree US Quality Dividend Growth UCITS ETF - USD 07/09/2018 IE00BZ56RD98 72491 USD 1,629,324.55 22.4762
WisdomTree US Quality Dividend Growth UCITS ETF - USD Acc 07/09/2018 IE00BZ56RG20 658320 USD 15,193,279.69 23.0789
WisdomTree US Small Cap Dividend UCITS ETF 07/09/2018 IE00BQZJBT94 650000 USD 13,901,920.54 21.3876 Reported by GlobeNewswire 19 minutes ago.

Fluidigm Announces Co-Marketing Agreement with Visiopharm to Expand and Simplify Imaging Mass Cytometry Data Analysis

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Visiopharm Phenomap software presented at the Fluidigm Imaging Mass Cytometry User Group Meeting, expanding the suite of Hyperion Imaging System data analysis tools for translational and clinical research

SOUTH SAN FRANCISCO, Calif., Sept. 10, 2018 (GLOBE NEWSWIRE) -- Fluidigm Corporation (NASDAQ:FLDM) and Visiopharm A/S today announced a co-marketing relationship to automate image analysis for Imaging Mass Cytometry™ (IMC™). Under the terms of this agreement, Fluidigm and Visiopharm will cooperatively promote Visiopharm^® image analysis software in conjunction with the Fluidigm^® Hyperion™ Imaging System, MCD™ Viewer software and related Maxpar^® antibodies and kits.Developed using proven Fluidigm CyTOF^® technology, the Hyperion Imaging System surpasses the inherent limitations of fluorescence detection by using highly pure metal tags that are separated by mass instead of by wavelength. Setting a new standard in highly multiplexed protein detection, the system enables researchers to simultaneously detect up to 37 markers from a single tissue section by IMC. Providing comprehensive analysis of cellular phenotypes and their interrelationships within the spatial context of the tissue microenvironment, IMC is aiding researchers around the world to uncover meaningful new insights in health and disease.

“We are committed to maximizing the full potential of mass cytometry to deeply interrogate tissue and tumor samples,” said Chris Linthwaite, President and CEO of Fluidigm. “Today we are excited to announce our agreement with Visiopharm, a leader in quantitative digital pathology software solutions. Together with Visiopharm, we are proud to bring new software capabilities to our growing IMC community.”

On September 11, Visiopharm will present its Phenomap™ software at the Fluidigm Imaging Mass Cytometry User Group Meeting in Seattle. Developed as an expansion of the Oncotopix^® Discovery platform, Phenomap enables researchers to perform automated analysis of images generated by the Hyperion Imaging System. Offered as a licensed software solution from Visiopharm, Phenomap provides automated cell segmentation and phenotyping of cell classes in addition to powerful visualization of cell populations with phenotypic charting and t-SNE clustering. 

“The collaboration between Fluidigm and Visiopharm will provide scientists novel tools to understand the biology of cancer, including the phenotyping of cells within the tumor microenvironment,” said Michael Grunkin, CEO of Visiopharm. “Our complementary technologies provide an entirely new research approach to drive drug-diagnostic co-development on a tissue-based platform, with the potential to also provide a new framework for precision medicine in cancer.”

“Collaborating to provide high-value automated data analysis solutions for the Hyperion Imaging System is essential to our strategy to empower routine use of this powerful technology,” continued Linthwaite. “By introducing automation to the MCD™ Viewer analysis pipeline, Phenomap further expands the capabilities of the Hyperion Imaging System to advance our understanding of human disease and improve the future of care.”

*About Visiopharm*
Visiopharm is a world leader in Augmented Pathology™ solutions. Leading biopharmaceutical companies, contract research organizations (CROs), academic medical centers, and hospital diagnostic pathology labs all over the world utilize the Oncotopix platform for tissue-based research and diagnostics. Oncotopix provides scientists and pathologist with a scalable software solution that fits the needs and volumes of both research and diagnostic labs. Over the past 16 years Visiopharm has grown into an international business with over 800 installations and countless more users. Visiopharm software is featured in over 1,350 scientific publications since 2010 and is compatible with leading slide scanning systems and data management software. A growing network of authorized distributors and integration partners support the growth of Visiopharm solutions on several continents including North America, Europe, and Asia. Our headquarters is in the Medicon Valley of Denmark, with a branch office in the United Kingdom and a North American office in Broomfield, Colorado.

*About Fluidigm *
Fluidigm (NASDAQ:FLDM) develops, manufactures, and markets life science analytical and preparatory systems for markets such as mass cytometry, high-throughput genomics, and single‑cell genomics. We sell to leading academic institutions, clinical research laboratories, and pharmaceutical, biotechnology, and agricultural biotechnology companies worldwide. Our systems are based on proprietary microfluidics and multiparameter mass cytometry technology and are designed to significantly simplify experimental workflow, increase throughput, and reduce costs while providing excellent data quality. Fluidigm products are provided for Research Use Only. Not for use in diagnostic procedures.

We use our website (www.fluidigm.com), corporate Twitter account (@fluidigm), Facebook page (https://www.facebook.com/fluidigm), and LinkedIn page (https://www.linkedin.com/company/fluidigm-corporation) as channels of distribution of information about our products, our planned financial and other announcements, our attendance at upcoming investor and industry conferences, and other matters. Such information may be deemed material information, and we may use these channels to comply with our disclosure obligations under Regulation FD. Therefore, investors should monitor our website and our social media accounts in addition to following our press releases, SEC filings, public conference calls, and webcasts.

Fluidigm, the Fluidigm logo, CyTOF, Hyperion, Imaging Mass Cytometry, IMC, Maxpar, and MCD are trademarks or registered trademarks of Fluidigm Corporation. Oncotopix is a registered trademark of Visiopharm.

*Forward-Looking Statement for Fluidigm *
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, among others, statements regarding the anticipated benefits of newly introduced products and the growth and potential of Imaging Mass Cytometry research. Forward-looking statements are subject to numerous risks and uncertainties that could cause actual results to differ materially from currently anticipated results, including but not limited to risks relating to challenges inherent in developing, manufacturing, launching, marketing, and selling new products; potential product performance and quality issues; intellectual property risks; and competition. Information on these and additional risks and uncertainties and other information affecting Fluidigm business and operating results is contained in Fluidigm’s Annual Report on Form 10-K for the year ended December 31, 2017, and in its other filings with the Securities and Exchange Commission, including the Fluidigm Quarterly Report on Form 10-Q for the quarter ended June 30, 2018. These forward-looking statements speak only as of the date hereof. Fluidigm disclaims any obligation to update these forward-looking statements except as may be required by law.

*Contacts: *

*Visiopharm*
Amanda Lowe
Senior Vice President, Operations
877 843 5268 ext. 705
alo@visiopharm.com 

*Fluidigm*
*Media: *
Michaeline Bunting
Senior Director, Marketing
650 737 4190
michaeline.bunting@fluidigm.com 

*Investors:*
Agnes Lee
Vice President, Investor Relations
650 416 7423
agnes.lee@fluidigm.com  Reported by GlobeNewswire 2 hours ago.

Europe leads fightback after Asian shares floored again

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Gains in Europe helped steady global stock markets on Monday, after rising anxiety about the U.S.-China trade war and further Fed rate hikes gave Asia its longest losing streak since the end of 2015. Reported by Reuters 1 hour ago.
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